9 -7 (69) 2024 - Urokov Sh.T., Abidov U.O. - THE DYNAMICS OF CHANGES IN BLOOD BIOCHEMICAL PARAMETERS UNDER THE INFLUENCE OF PLASMAPHERESIS IN BENIGN PROLONGED MECHANICAL JAUNDICE SYNDROME

THE DYNAMICS OF CHANGES IN BLOOD BIOCHEMICAL PARAMETERS UNDER THE INFLUENCE OF PLASMAPHERESIS IN BENIGN PROLONGED MECHANICAL JAUNDICE SYNDROME

Urokov Sh.T. - Bukhara State Medical Institute named after Abu Ali ibn Sina, Bukhara branch of the Republican Scientific Center for Emergency Medical Care, Uzbekistan

Abidov U.O. - Bukhara State Medical Institute named after Abu Ali ibn Sina, Bukhara branch of the Republican Scientific Center for Emergency Medical Care, Uzbekistan

Boltayev N.R. - Bukhara State Medical Institute named after Abu Ali ibn Sina, Bukhara branch of the Republican Scientific Center for Emergency Medical Care, Uzbekistan

Resume

Mechanical jaundice occurs when the flow of bile, which is necessary for digestion, is blocked. This blockage, often caused by gallstones or inflammation, leads to an accumulation of bile in the liver, causing cell damage and potentially leading to liver failure. Traditional treatments sometimes fail to reverse these complications, so therapeutic plasmapheresis has emerged as a potential alternative. This extracorporeal procedure cleans the patient's blood, removing toxins and inflammatory mediators and potentially stopping or reversing liver damage. 112 patients were monitored and received treatment. The patients were divided into three groups: a control group of 46 patients who underwent retrospective endoscopic decompression and standard conservative treatment, and a main group of 66 prospective patients who received endoscopic decompression, nasobiliary drainage (NZBD), early plasmapheresis (rPF), and glutathione and Remaxol treatments. The study examined the dynamics of biochemical markers of mechanical jaundice complicated by liver failure after various combinations of these therapeutic algorithms.

Key words: long-term mechanical jaundice, plasmapheresis, liver failure.

First page

54

Last page

61

For citation:Urokov Sh.T., Abidov U.O., Boltayev N.R. - THE DYNAMICS OF CHANGES IN BLOOD BIOCHEMICAL PARAMETERS UNDER THE INFLUENCE OF PLASMAPHERESIS IN BENIGN PROLONGED MECHANICAL JAUNDICE SYNDROME//New Day in Medicine 7(69)2024 54-61 https://newdayworldmedicine.com/en/new_day_medicine/7-69-2024

List of References

1. Wang L., Yu W.F. Obstructive jaundice and perioperative management. //Acta Anaesthesiol. Taiwan. 2014;52(1):22-29.
2. Гальперин Э.И. Механическая желтуха: состояние “мнимой стабильности”, последствия “второго удара”, принципы лечения. //Анналы хирургической гепатологии. 2011;16(3):16-25.
3. Гальперин Э.И., Момунова О.Н. Классификация тяжести механической желтухи. //Хирургия. Журнал им. Н.И. Пиро¬гова. 2014;1:5-9.
4. Еремеева Л.Ф., Бердников А.П., Мусаева Т.С., Заболотских И.Б. Прогнозирование летальности при острой печеночной недостаточности. //Анестезиол. и реаниматол. 2013;(6):14-6.
5. Еремеева ЛФ, Ямпольский АФ. Экстракорпоральные методы лечения у пациентов с печеночно-клеточной недостаточностью. //Актуальные проблемы транспортной медицины. 2010;(4):139-49.
6. Иоффе ИВ, Потеряхин ВП. Печеночная недостаточность у больных с механической желтухой неопухолевого генеза. //Український журнал клінічноїта 2020.
7. Натальский АА, Тарасенко СВ, Зайцев ОВ, Песков ОД. Современные представления о печеночной недостаточности в хирургии. //Российский медико-биологический вестник имени академика И.П. Павлова. 2014;(4):138-47.
8. Руководство по хирургии желчных путей. Под ред. Э.И. Гальперина, П.С. Ветшева. 2-е изд. М.: Видар-М, 2009; 568 с.
9. Шевченко Ю.Л., Ветшев П.С., Стойко Ю.М., Левчук А.Л., Конторщикова Е.С. Приоритетные направления в лечении больных с механической желтухой. //Анналы хирургической гепатологии. 2011;16(3):9-15.

   file

   download