24 -4 (36) 2021 — Tilyabov I.A. — STREPTOZOTOCIN MODELS OF EXPERIMENTAL DIABETES MELLITUS

STREPTOZOTOCIN MODELS OF EXPERIMENTAL DIABETES MELLITUS

Tilyabov I.A. Tashkent Medical Academy

Resume

The aim of the study was to study the literature data on the creation of a model of stable experimental diabetes mellitus (DM) in laboratory rats using streptozotocin (STC). It was revealed that streptozotocin models of mixed or type 2 diabetes are most widely used in modern experimental diabetology. The sensitivity to the introduction of these diabetogenic compounds can significantly depend not only on the species, but also on the genetic line of the animal and its age. Studies are presented in which type 2 diabetes was simulated by the administration of streptozotocin (STC) to laboratory rodents (mice and rats).

Key words: experimental diabetes mellitus, streptozotocin, rats, glycemia, hyperglycemia.

First page

112

Last page

116

For citation: Tilyabov I.A. STREPTOZOTOCIN MODELS OF EXPERIMENTAL DIABETES MELLITUS//New Day in Medicine4(36)2021 112-116 https://cutt.ly/4TrLQmp

LIST OF REFERENCES:

  1. Baranov V.G., Sokoloverova I.M., Gasparyan E.G., Yaroshevskiy Yu.A., Nikitin A.I. Eksperimental’nyy sakharnyy diabet. Rol’ v klinicheskoy diabetologii. L.: Nauka, 1983: 240.
  2. Bayrasheva V.K. Modelirovaniye sakharnogo diabeta i diabeticheskoy nefropatii v eksperimente // Elektronnyy zhurnal «Sovremennyye problemy nauki i obrazovaniya». 2015. № 4.
  3. Mazo V.K., Sidorova Yu.S., Kochetkova A.A. Geneticheskiye modeli sakharnogo diabeta 2 tipa na myshakh dlya otsenki effektivnosti minornykh biologicheski aktivnykh veshchestv pishchi // Vopr. pitaniya. 2015. T. 84, № 6. S. 63-68.
  4. Mazo V.K., Murashev A.N., Sidorova Yu.S., Zorin S.N., Kochetkova A.A. Geneticheskiye modeli diabeta tipa 2 na krysakh dlya otsenki effektivnosti minornykh biologicheski aktivnykh veshchestv pishchi // Vopr. pitaniya. 2014. T. 83, № 6. S. 25-31.
  5. Snigur G.L., Smirnov A.V., Shmidt M.V., Pocheptsov M.YA. i dr. Sravnitel’nyye aspekty ul’trastrukturnykh izmeneniy insulotsitov pankreaticheskikh ostrovkov pri eksperimental’nom sakharnom diabete // Volgograd. nauch.-med. zhurn. 2012. № 1. C. 108-111.
  6. Ganda OP, Rossi AA, Like AA. Studies on streptozotocin diabetes. Diabetes. 1976; 25: 595-603.
  7. Gandhi G.R., Stalin A., Balakrishna K. et al. Insulin sensitization via partial agonism of PPARgamma and glucose uptake through translocation and activation of GLUT4 in PI3K/p-Akt signaling pathway by embelin in type 2 diabetic rats // Biochim. Biophys. Acta. 2013. Vol. 1830. P. 2243-2255.
  8. Katsumata K, Katsumata K, Jr., Katsumata Y. Protective effect of diltiazem hydrochloride on the occurrence of alloxan- or streptozotocin-induced diabetes in rats. Horm Metab Res. 1992; 24: 508-510.
  9. Nir Т, Melton DA, Dor Y. Recovery from diabetes in mice by β cell regeneration. The Journal of Clinical Investigation. 2007; 117 (9): 2553-2561.
  10. Quaranta P, Antonini S, Spiga S, Mazzanti B, Curcio M, Mulas G, Diana M, Marzola P, Mosca F, Longoni B. Cotransplantation of endothelial progenitor cells and pancreatic islets to induce long-lasting normoglycemia in streptozotocin-treated diabetic rats. PLoS One. 2014 Apr 14; 9 (4): e94783. https://doi.org/10.1371/journal.pone.0094783. eCollection 2014.
  11. Olatunji L.A., Okwusidi J.I., Soladoye A.O. Antidiabetic Effect of anacardium occidentale stem-bark in fructose-diabetic rats // Pharm. Biol. 2005. Vol. 43, N 7. P. 589-593. 48.
  12. Patel J., Iyer A., Brown L. Evaluation of the chronic complication of diabetes in a high fructose diet in rats // Indian J. Biochem. Biophys. 2009. Vol. 46. P. 66-72.
  13. Szkudelski T. Streptozotocin-nicotinamide-induced diabetes in the rat. Characteristics of the experimental model. Exp Biol Med (Maywood). 2012 May; 237 (5): 481-490. https://doi.org/10.1258/ebm.2012.011372. Epub 2012 May 22.
  14. Wilson R.D, Islam M.S. Fructose-fed streptozotocin-injected rat: an alternative model for type diabetes // Pharmacol. Rep. 2012. Vol. 64, N 1. Р. 129-139.
  15. Wu Y., Ouyang J.P., Zhou Y.F. et al. Mechanism of improving effect of losartan on insulin sensitivity of non-insulin-dependent diabetes mellitus rats // Acta Physiologica Sinica. 2004. Vol. 56. P. 539549.
  16. Zhou Y.S., Gao Y., Guo X.H. et al. Effects of timely insulin treatment on protection of beta cells in a rat model of type 2 diabetes mellitus // Chin. Med. J. (Engl). 2004. Vol. 117. P. 15231529.
  17. Zhang M., Lv X.Y., Li J., Xu Z.G., Chen L. The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model // Exp. Diabetes Res. 2008. Article ID 704045. doi: 10.1155/2008/704045. 47.

file

download