65 -7 (69) 2024 - Mukhamedzhanova M.Kh., Shadzhanova N.S. - ANALYSIS OF LIVER FIBROSIS BY NON-INVASIVE METHODS IN PATIENTS WITH HEPATITIS C IN ASSOCIATION WITH CHRONIC HEART FAILURE

ANALYSIS OF LIVER FIBROSIS BY NON-INVASIVE METHODS IN PATIENTS WITH HEPATITIS C IN ASSOCIATION WITH CHRONIC HEART FAILURE

Mukhamedzhanova M.Kh. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Shadzhanova N.S. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Chronic hepatitis C (HCV infection) is one of the most pressing medical and social problems in the world, due to the widespread, consistently high incidence and widespread prevalence, as well as the enormous economic costs of diagnostic and treatment processes. Purpose of the study: to determine the prognostic value of non-invasive methods of liver fibrosis index and compare the indicators with elastometry indicators in patients with hepatitis C in association with CHF. The study material included 110 patients with chronic viral hepatitis C undergoing treatment at the Bukhara Regional Multidisciplinary Medical Center and the Regional Infectious Diseases Hospital. Own results. To achieve this goal, we studied the non-invasive liver fibrosis indices (LPI) APRI and FIB-4 in the study group. These tests were chosen because these are the test indicators that are studied in each hospital according to the standard. When assessing the liver fibrosis index in late patients with comorbidity of chronic hepatitis C + CHF + anemia, it was found that for the APRI scales, AUC = 0.878 and AUC = 0.878, respectively, for the FIB4 scale, it was determined that AUC = 0.823 and AUC = 0.725, respectively, have a prognostic value. Conclusions. Non-invasive FPI methods APRI test and FIB4 scales are quite simple, reliable and economical; their use can make it possible to approximately understand the presence of high-stage fibrosis, based on publicly available indicators, and can be recommended as a screening examination.

Key words: Chronic viral hepatitis C, chronic heart failure, liver fibrosis index, APRI scale, FIB-4 scale, elastometry.

First page

377

Last page

381

For citation:Mukhamedzhanova M.Kh., Shadzhanova N.S. - ANALYSIS OF LIVER FIBROSIS BY NON-INVASIVE METHODS IN PATIENTS WITH HEPATITIS C IN ASSOCIATION WITH CHRONIC HEART FAILURE//New Day in Medicine 7(69)2024 377-381 https://newdayworldmedicine.com/en/new_day_medicine/7-69-2024

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