68 -7 (69) 2024 - S.O. Inoyatova - GENETIC FACTORS OF STROKE

GENETIC FACTORS OF STROKE

S.O. Inoyatova - Tashkent State Dental Institute

Resume

The relevance of stroke around the world is beyond doubt due to its medical, social and economic significance. The article provides information on the genetic prerequisites for the development of a stroke. Genetic variants that have already been identified explain only a small proportion of the overall risk of stroke. The search for new genes associated with stroke can reveal new pathways involved in the pathogenesis of stroke and suggest new approaches to treatment. Thus, the search for new ones and the study of the prevalence of polymorphic variants of genes in various systems involved in the pathogenesis of ischemic and hemorrhagic stroke will make it possible to identify the most significant genetic risk factors for this disease for the treatment and prevention of this disease.

Keywords: stroke, heredity, risk factors, genes.

First page

394

Last page

401

For citation:S. O. Inoyatova - GENETIC FACTORS OF STROKE//New Day in Medicine 7(69)2024 394-401 https://newdayworldmedicine.com/en/new_day_medicine/7-69-2024

List of References

  1. Valery L Feigin, Michael Brainin, Bo Norrving, Sheila Martins, Ralph L Sacco, Werner Hacke, Marc Fisher, Jeyaraj Pandian, Patrice Lindsay. World Stroke Organization (WSO): Global Stroke Fact Sheet 2022 //Int J Stroke. 2022 Apr;17(4):478. doi: 10.1177/17474930221080343.
  2. Joosup Kim, Muideen T Olaiya, Deidre A De Silva, Bo Norrving, Jackie Bosch, Diana A de Sousa et al. Global Stroke Statistics 2023: Availability of reperfusion services around the world // International Journal of stroke //Official Journal of the world stroke organization, 2022;17(2):1-43.
  3. Махамадходжаева М.А., Дониев И. Факторы риска сердечно-сосудистых заболеваний // Scientific progress? 2021;2(6):1902-1906. ISSN: 2181-1601
  4. Батуренец В.Г., Шевченко П.П., Карпов С.М. Геморрагический инсульт: клиника, диагностика, лечение, реабилитация и профилактика //Современная медицина, 2021;1(20):61-64.
  5. Ишемический инсульт и транзиторная ишемическая атака у взрослых. Клинические рекомендации. 2021; 260.
  6. Есин Р.Г., Есин О.Р., Хайруллин И.Х. Болезнь мелких сосудов: патогенетические подтипы, возможные лечебные стратегии. //Consilum Mediсum. 2016;18(2):104-108.
  7. Markus, H.S. Stroke genetics: prospects for personalized medicine. //BMC, 2012;10:113 https://doi.org/10.1186/1741-7015-10-113.
  8. Кимельфельд Е.И., Кольцова Е.А., Петрова Е.А., Гудкова В.В., Стаховская Л.В., Тупицына Т.В., и др. Ассоциация генов системы гемостаза с риском развития ишемического инсульта у пациентов в возрасте до 50 лет. //Журнал неврологии и психиатрии им. C.C. Корсакова. 2018;118(9-2):14-21. https://doi.org/10.17116/jnevro201811809214
  9. Шишкова В.Н., Адашева Т.В., Ременник А.Ю., Валяева В.Н., Шкловский В.М. Прогностическая значимость клинико-антропометрических, биохимических, метаболических, сосудисто-воспалительных и молекулярно-генетических маркеров в развитии первого ишемического инсульта. //Журнал неврологии и психиатрии им. C.C. Корсакова. 2018;118(2):4-11. https://doi.org/10.17116/jnevro2018118214-11
  10. Bellenguez C., Bevan S., Gschwendtner A. et al. Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. //Nat Genet. 2012;44:328-333.
  11. Kilarski L.L., Achterberg S., Devan W.J. et al. Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12. //Neurology. 2014;83:678-685.
  12. Bevan S., Traylor M., Adib-Samii P. et al. Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations. //Stroke. 2012;43:3161-3167.
  13. Carty C.L., Keene K.L., Cheng Y.C. et al. Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans. //Stroke. 2015;46(8):2063-2068.
  14. Lemmens R., Buysschaert I., Geelen V. et al. The association of the 4q25 susceptibility variant for atrial fibrillation with stroke is limited to stroke of cardioembolic etiology. //Stroke. 2010;41:1850-1857.
  15. French C.R., Seshadri S., Destefano A.L. et al. Mutation of FOXC1 and PITX2 induces cerebral small-vessel disease. //J Clin Invest. 2014;124:4877-4881.
  16. Traylor M., Makela K.M., Kilarski L.L. et al. A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach. //PLoS Genet. 2014;10:1004469.
  17. Block F, Dafotakis M. Cerebral Amyloid Angiopathy in Stroke Medicine. //Dtsch Arztebl Int. 2017;114(3):37-42. https://doi.org/10.3238/arztebl.2017.0037
  18. Deloukas P., Kanoni S., Willenborg C. et al. Large-scale association analysis identifies new risk loci for coronary artery disease. //Nat Genet. 2013;45:25–33.
  19. Kato N., Loh M., Takeuchi F. et al. Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. //Nat Genet. 2015;47:1282-1293.
  20. Gündoğdu AA, Kotan D, Alemdar M, Ayas ZÖ. Fabry Disease Diagnosis in a Young Stroke Patient: A Case Report. //Noro Psikiyatr Ars. 2018;55(3):291-292. https://doi.org/10.5152/npa.2017.19189

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