• Home
  • NEW DAY MEDICINE
  • 9 (71) 2024
  • 17 -9 (71) 2024 - Abdukadirova M.A., Khikmatullaeva A.S., Mannobjonov P.B., Ibadullaeva N.S., Lokteva L.M. - HUMAN PAPILLOMA VIRUS: PATHOGENESIS, DIAGNOSIS, CLINICAL AND TREATMENT

17 -9 (71) 2024 - Abdukadirova M.A., Khikmatullaeva A.S., Mannobjonov P.B., Ibadullaeva N.S., Lokteva L.M. - HUMAN PAPILLOMA VIRUS: PATHOGENESIS, DIAGNOSIS, CLINICAL AND TREATMENT

HUMAN PAPILLOMA VIRUS: PATHOGENESIS, DIAGNOSIS, CLINICAL AND TREATMENT

Abdukadirova M.A. - The Research Institute of Virology of the Republican specialized scientific practical medical center of epidemiology, microbiology, infectious and parasitic diseases

Khikmatullaeva A.S. - The Research Institute of Virology of the Republican specialized scientific practical medical center of epidemiology, microbiology, infectious and parasitic diseases

Mannobjonov P.B. - The Tashkent Medical Academy

Ibadullaeva N.S. - The Research Institute of Virology of the Republican specialized scientific practical medical center of epidemiology, microbiology, infectious and parasitic diseases

Lokteva L.M. - The Research Institute of Virology of the Republican specialized scientific practical medical center of epidemiology, microbiology, infectious and parasitic diseases

Resume

This article presents an analysis of the literature data on the study of HPV pathogenesis, diagnosis, clinic and treatment. HPV is a significant public health problem requiring comprehensive prevention, screening and treatment measures. Diagnosis of HPV includes PCR, cytologic examination, and total viral load determination. Cytologic examination of cervical mucosal smears identifies cells characteristic of HPV infection. Clinical manifestations of HPV range from an asymptomatic course to the development of anogenital warts and cancer. Approximately 90% of infected individuals are able to self-manage the infection; however, persistent infection with high-risk HPV types can lead to cancer. HPV treatment is aimed at eliminating external manifestations and minimizing the development of complications, including cancer. Antiviral agents, immune-stimulating drugs, and medical destruction methods to remove papillomas are used. HPV vaccine prophylaxis has proven effective and safe in reducing the incidence of cancers associated with this virus. Despite the lack of specific therapy, existing methods of treatment and prevention, including vaccination, can effectively control the spread of HPV and related diseases.

Key words: human papillomavirus, pathogenesis, diagnosis, clinic, treatment.

First page

83

Last page

90

For citation:Abdukadirova M.A., Khikmatullaeva A.S., Mannobjonov P.B., Ibadullaeva N.S., Lokteva L.M. - HUMAN PAPILLOMA VIRUS: PATHOGENESIS, DIAGNOSIS, CLINICAL AND TREATMENT//New Day in Medicine 9(71)2024 83-90 https://newdayworldmedicine.com/en/new_day_medicine/9-71-2024

List of References

  1. Milner D.A. Diagnostic Pathology: Infectious Diseases. //Elsevier Health Sciences, 2015., Р.40. ISBN 9780323400374. Archived from the original on 11 September 2017.
  2. de Villiers E.-M., Fauquet C., Broker T. R., Bernard H.-U., zur Hausen H. Phylogenetic tree containing sequences of 118 papillomavirus types. //Virology. 2004;324:17-24.
  3. "Human papillomavirus (HPV) and cervical cancer - WHO". World Health Organization. 22 February 2022. Archived from the original on 22 April 2023.
  4. Ljubojevic S, Skerlev M. HPV-associated diseases. // Clinics in Dermatology. 2014; 32(2):227–34. doi:10.1016/j.clindermatol.2013.08.007. PMID 24559558.
  5. Anjum Fatima; Zohaib Jamal. Oropharyngeal Squamous Cell Carcinoma. // Definitions, 4 December 2020. doi:10.32388/G6TG1L. PMID 33085415. S2CID 229252540.
  6. Nejo YT, Olaleye DO and Odaibo GN. Prevalence and Risk Factors for Genital Human Papillomavirus Infections Among Women in Southwest Nigeria. //Arch Basic Appl Med. 2018;6(1):105-112.
  7. Аральди Р.П., Сант'Ана Т.А., Модоло Д.Г., де Мело Т.К., Спадаччи-Морена Д.Д., де Кассия Стокко Р., Черутти Х.М., де Соуза Э.Б. Биология рака, связанного с вирусом папилломы человека (ВПЧ): обзор. //Биомед Фармаколог. 2018 Октябрь; 106:1537-1556.
  8. Бажукова Н.Н., Возовик А.В. Современный взгляд на патогенез папилломавирусной инфекции //Вестник Уральской медицинской академической науки, 2014; 5:116-120.
  9. Бергвалл М., Меленди Т., Аршамбо Дж. Белки Е1. //Вирусология. 2013; 445:35-56. doi: 10.1016/j.virol.2013.07.020.
  10. Макбрайд А.А. Белки Е2 папилломавируса. //Вирусология. 2013;445:57-79. doi: 10.1016/j.virol.2013.06.006.
  11. Меленди Т., Седман Дж., Стенлунд А. Клеточные факторы, необходимые для репликации ДНК папилломавируса. // Дж. Вирол. 1995 год; 69: 7857–7867.
  12. Eileen M. Burd* Human Papillomavirus and Cervical Cancer. Clin Microbiol Rev. 2003 Jan; 16(1):1-17. doi: 10.1128/CMR.16.1.1-17.2003
  13. Киселев В.И., Киселев О.И., Кулаков В.И. и др. Этиологическая роль вируса папилломы человека в развитии рака шейки матки: генетические и патогенетические механизмы, возможности терапии и профилактики //Гинекология, 2004;4:174-180.
  14. Бахтияров К.Р., Щукина А.С. Вирус папилломы человека. //Современный взгляд на Проблему и здоровье и образование в XXI веке. – С.37-42. http://dx.doi.org/10.26787/nydha-2226-7425-2017-19-12-37-42.
  15. Bzhalava D., Muhr L.S., Lagheden C., Ekström J., Forslund O., Dillner J., Hultin E. Deep sequencing extends the diversity of human papillomaviruses in human skin. //Sci Rep. 2014;4:5807. doi: 10.1038/srep05807.
  16. Nagai Y. Persistence of human papillomavirus infection after therapeutic conization for CIN III: is it an alarm for disease recurrence? //Gynecol Oncol. 2000;79(2):294-299. doi: 10.1006/gyno.2000.5952.
  17. Прилепская В.Н., Довлетханова Э.Р. Особенности диагностики, клинической картины и лечения заболеваний, ассоциированных с папиллома-вирусной инфекцией. //Гинекология. 2013;(5):7-12. Режим доступа: http:// www.fesmu.ru/elib/Article.aspx?id=289240.
  18. Киселев В.И., Аполихина И.А., Муйжнек Е.Л., Денисова Е.Д. Патогенетические подходы к лечению ВПЧ-ассоциированных заболеваний шейки матки. В: Прилепская В.Н. (ред.). Патология шейки матки и гениталь-ные инфекции. М.: МЕД пресс-информ; 2008. С. 87-93.
  19. Stanley M. Pathology and epidemiology of HPV infection in females. //Gynecologic Oncology. 2010;117 (supplement 2):S5–S10. doi: 10.1016/j.ygyno.2010.01.024.
  20. Garcia-Chacon R., Velasco-Ramirez S. F., Flores-Romo L., Daneri-Navarro A. Immunobiology of HPV infection. Archives of Medical Research. 2009;40(6):443-448. doi: 10.1016/j.arcmed.2009.05.003.

    file

    download