28 -9 (71) 2024 - Sanokulova S.A. - IMPORTANCE OF HOMOCYSTEINE IN LIVER DISEASES

IMPORTANCE OF HOMOCYSTEINE IN LIVER DISEASES

Sanokulova S.A. - Bukhara State Medical Institute named after Abu Ali ibn Sino

Resume

Numerous clinical and epidemiological studies have identified elevated plasma homocysteine levels as a risk factor for atherosclerotic vascular disease and thromboembolism. Hyperhomocysteinemia can develop due to defects in genes that metabolize homocysteine; nutritional conditions leading to a deficiency of vitamins B6, B12 or folic acid; or chronic alcohol use. Homocysteine is an intermediate product of methionine metabolism, which occurs primarily in the liver. Impaired liver function leads to changes in the metabolism of methionine and homocysteine; however, the molecular basis of such changes is not fully understood. In addition, the mechanisms of homocysteine-induced cellular toxicity are not fully defined.

Key words: homocysteine, metabolism, liver, cirrhosis, vitamins B6, B12

First page

142

Last page

145

For citation:Sanokulova S.A. - IMPORTANCE OF HOMOCYSTEINE IN LIVER DISEASES//New Day in Medicine 9(71)2024 142-145 https://newdayworldmedicine.com/en/new_day_medicine/9-71-2024

List of References

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