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  • 30 -9 (71) 2024 - J.Dj. Tuychiev, L.N. Tuychiev - ANALYSIS OF BACTERIAL CO-INFECTIONS IN HOSPITALIZED PATIENTS WITH COVID-19: FREQUENCY, PATHOGENS AND ANTIMICROBIAL RESISTANCE

30 -9 (71) 2024 - J.Dj. Tuychiev, L.N. Tuychiev - ANALYSIS OF BACTERIAL CO-INFECTIONS IN HOSPITALIZED PATIENTS WITH COVID-19: FREQUENCY, PATHOGENS AND ANTIMICROBIAL RESISTANCE

ANALYSIS OF BACTERIAL CO-INFECTIONS IN HOSPITALIZED PATIENTS WITH COVID-19: FREQUENCY, PATHOGENS AND ANTIMICROBIAL RESISTANCE

J.Dj. Tuychiev - Tashkent Medical Academy

L.N. Tuychiev - Tashkent Medical Academy

Resume

The frequency of secondary bacterial infection in sputum of patients with COVID-19 was studied in 672 adult patients with COVID-19. The most common pathogens were K.pneumoniae (16,4%), S.aureus (12,2%), and E.coli (5,7%). Notably, P.aeruginosa was more frequently found in critically ill patients. Antimicrobial resistance testing revealed high resistance rates among K.pneumoniae and E.coli to beta-lactam antibiotics, with better sensitivity to fluoroquinolones and carbapenems. P.aeruginosa and A.baumannii also showed significant resistance to many antibiotics. The study underscores the critical role of continuous monitoring and tailored antimicrobial stewardship programs to combat the rising challenge of antimicrobial resistance in the context of the COVID-19 pandemic.

Key words. COVID-19, bacterial co-infections, antimicrobial resistance

First page

150

Last page

155

For citation:J.Dj. Tuychiev, L.N. Tuychiev - ANALYSIS OF BACTERIAL CO-INFECTIONS IN HOSPITALIZED PATIENTS WITH COVID-19: FREQUENCY, PATHOGENS AND ANTIMICROBIAL RESISTANCE//New Day in Medicine 9(71)2024 150-155 https://newdayworldmedicine.com/en/new_day_medicine/9-71-2024

List of References

  1. Lansbury L, Lim B, Baskaran V, Lim WS. Co-infections in people with COVID-19: a systematic review and meta-analysis. //J Infect. 2020;81(2):266-275. https://doi.org/10.1016/j.jinf.2020.05.046
  2. 2023 Antibacterial agents in clinical and preclinical development: an overview and analysis. Geneva: World Health Organization; 2024. Licence: CC BY-NC-SA 3.0 IGO.
  3. Du Q, Zhang D, Hu W, Li X, Xia Q, Wen T, Jia H. Nosocomial infection of COVID‑19: A new challenge for healthcare professionals (Review). //Int J Mol Med. 2021 Apr;47(4):31. doi: 10.3892/ijmm.2021.4864. Epub 2021 Feb 4. PMID: 33537803; PMCID: PMC7891837.
  4. Arun N, Saurabh K, Muni S, Kumari N, Dev A. A Comparative Study of Bacterial Infections Between COVID-19 and Non-COVID-19 Patients With Respect to Different Isolates and Their Antibiotic Sensitivity Pattern. //Cureus. 2023 Jun 13;15(6):e40387. doi: 10.7759/cureus.40387.
  5. Kaçmaz, B., Keske, Ş., Sişman, U. et al. COVID-19 associated bacterial infections in intensive care unit: a case control study. //Sci Rep 13, 13345 (2023).
  6. Bradley J Langford, Miranda So, Marina Simeonova, Valerie Leung, Jennifer Lo, Tiffany Kan, Sumit Raybardhan, Mia E Sapin, Kwadwo Mponponsuo, Ashley Farrell, Elizabeth Leung, Jean-Paul R Soucy, Alessandro Cassini, Derek MacFadden, Nick Daneman, Silvia Bertagnolio, Antimicrobial resistance in patients with COVID-19: a systematic review and meta-analysis, The Lancet Microbe, 2023;4(3):179-191.
  7. Grinbaum R.S., Kiffer C.Rv. Bacterial infections in COVID-19 patients: a review. Rev Assoc Med Bras (1992). 2021 Dec;67(12):1863-1868.
  8. Yang X, Li X, Qiu S, Liu C, Chen S, Xia H, Zeng Y, Shi L, Chen J, Zheng J, Yang S, Tian G, Liu G, Yang L. Global antimicrobial resistance and antibiotic use in COVID-19 patients within health facilities: A systematic review and meta-analysis of aggregated participant data. //J Infect. 2024 Jul;89(1):106183. doi: 10.1016/j.jinf.2024.106183.

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