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  • 39 -9 (71) 2024 - Urokov. Sh.T., Abidov U.O., Salomov N.I. - GASTRODUODENAL ULCER AND BLEEDING IN PATIENTS WITH CIRRHOSIS OF THE LIVER: CURRENT DIAGNOSIS AND TREATMENT OPTIONS

39 -9 (71) 2024 - Urokov. Sh.T., Abidov U.O., Salomov N.I. - GASTRODUODENAL ULCER AND BLEEDING IN PATIENTS WITH CIRRHOSIS OF THE LIVER: CURRENT DIAGNOSIS AND TREATMENT OPTIONS

GASTRODUODENAL ULCER AND BLEEDING IN PATIENTS WITH CIRRHOSIS OF THE LIVER: CURRENT DIAGNOSIS AND TREATMENT OPTIONS

Urokov. Sh.T. - Bukhara State Medical Institute named after Abu Ali ibn Sina, Bukhara branch of the Republican Scientific Center for Emergency Medical Care Uzbekistan

Abidov U.O. - Bukhara State Medical Institute named after Abu Ali ibn Sina, Bukhara branch of the Republican Scientific Center for Emergency Medical Care Uzbekistan

Salomov N.I. - Bukhara State Medical Institute named after Abu Ali ibn Sina, Bukhara branch of the Republican Scientific Center for Emergency Medical Care Uzbekistan

Resume

Gastroduodenal ulcerative bleeding in patients with cirrhosis of the liver, they are a serious complication that requires a multidisciplinary approach in diagnosis and treatment. Cirrhosis of the liver complicates the course of peptic ulcer disease, increasing the risk of bleeding, which often leads to high mortality rates even with timely treatment. Modern diagnostic methods include endoscopic and laboratory tests, as well as non-invasive approaches to assess the condition of the liver and the degree of portal hypertension. The treatment is based on endoscopic endohemostasis and pharmacological preparations. The prognosis depends on the severity of cirrhosis and the effectiveness of treatment, but the risk of recurrence and mortality remains high. Despite the achievements of modern medicine, in patients with cirrhosis of the liver continues to be a challenge for doctors, requiring further research to improve methods of diagnosis, treatment and prevention.

Keywords: cirrhosis of the liver, gastroduodenal ulcers, bleeding.

First page

196

Last page

204

For citation:Urokov. Sh.T., Abidov U.O., Salomov N.I. - GASTRODUODENAL ULCER AND BLEEDING IN PATIENTS WITH CIRRHOSIS OF THE LIVER: CURRENT DIAGNOSIS AND TREATMENT OPTIONS//New Day in Medicine 9(71)2024 196-204 https://newdayworldmedicine.com/en/new_day_medicine/9-71-2024

List of References

  1. Гончарик И.И. Болезни желудка и кишечника: Справ. Пособие. - Минск: Высшей. шк., 1994; 160 с.
  2. Назыров Ф.Г., Уроков Ш.Т. //Хирургия Узбекистана 1999;1:3-4.
  3. "Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies" (Journal of Hepatology, 2006).
  4. Afessa B., Kubilis P.S. Upper gastrointestinal bleeding in patients with hepatic cirrhosis: clinical course and mortality prediction. //Am J Gastroenterol 2000;95:484-489.
  5. Amitrano L., Anna Guardascione M., Manguso F., Bennato R., Bove A., DeNucci C., et al. The effectiveness of current acute variceal bleed treatments in unselected cirrhotic patients: refining short-term prognosis and risk factors. //Am J Gastroenterol 2012;107:1872-1878.
  6. Augustin S, González A, Genescà J. Acute esophageal variceal bleeding: Current strategies and new perspectives. //World J Hepatol. 2016;8(9):293-305. DOI: 10.4254/wjh. v8. i9.293.
  7. Baveno V.I. Consensus Workshop. Methodology of diagnosis and therapy in portal hypertension. //J Hepatol. 2015;63(3):743-752. DOI: 10.1016/j.jhep.2015.05.022.
  8. Bjørnsson E, Kalaitzakis E, et al. Incidence and prognosis of gastrointestinal bleeding in patients with cirrhosis. Gut. 2012.
  9. Cales P, Oberti F, Payen JL, et al. Liver biopsy in patients with cirrhosis and variceal bleeding. //Hepatology. 2000;32(3):528-536. DOI: 10.1053/jhep.2000.16611.
  10. Chen C.Y., Lin C.Y., Chang T.T. et al. A simple maneuver for placing an overtube during endoscopic variceal ligation (letter) //Gastrointest. Endosc. 1995;41(1):83.
  11. Cryer B. Spechler S.J. Peptic ulcer disease. In Sleisenger and Fordtran’s Gastrointestinal and Liver Disease 8th edn (eds Felman, M. et al.) 2006;1089-1110. (Saunders, Philadelphia, 2006).
  12. D’Amico G, De Franchis R, Cooperative Study Group. Upper digestive bleeding in cirrhosis. Post-therapeutic outcome and prognostic indicators. //Hepatology. 2003;38:599-612.
  13. D’Amico G, De Franchis R. Upper digestive bleeding in cirrhosis. Post-therapeutic outcome and prognostic indicators. //HEPATOLOGY 2003;38:599-612.
  14. De Franchis R, Baveno VI Faculty. Revising consensus in portal hypertension: report of the Baveno VI Consensus Workshop: stratifying risk and individualizing care for portal hypertension. //J Hepatol. 2015.
  15. Garcia-Tsao G, Sanyal AJ, et al. Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. //Hepatology. 2007.
  16. Goulis J, Armonis A, Patch D, Sabin C, Greenslade L, Burroughs AK. Bacterial infection is independently associated with failure to control bleeding in cirrhotic patients with gastrointestinal hemorrhage. //Hepatology vol. 1998;27:1207-12.
  17. Hearnshaw S. et al. Acute upper gastrointestinal bleeding in the UK: patient characteristics, diagnoses and outcomes in the 2007 UK audit. Gut 60, 1327–1335.
  18. Holland-Bill L, Christiansen CF, Gammelager H, Mortensen RN, Pedersen L, Sørensen HT. Chronic liver disease and 90-day mortality in 21 359 patients following peptic ulcer bleeding a Nationwide Cohort Study. //Aliment Pharmacol Ther 2015;41:564-572.
  19. Hsu YC, Lin JT, Chen TT, Wu MS, Wu CY. Long-term risk of recurrent peptic ulcer bleeding in patients with liver cirrhosis: a 10-year nationwide cohort study. //HEPATOLOGY 2012;56:698-750.
  20. Imoto L, Yoshida M., Shida Y., Iparraguirre H. Campylobacter pylori infection and gastric mucosal lesions in patients with chronic liber diseases //J. Gastroenterol. Hepatol. 1989;4(1):75-77.

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