79 -9 (71) 2024 - A.A. Davlyatova - THE ROLE OF ORAL DISEASES IN THE DEVELOPMENT OF POSTPARTUM SEPSIS IN PREGNANT WOMEN

THE ROLE OF ORAL DISEASES IN THE DEVELOPMENT OF POSTPARTUM SEPSIS IN PREGNANT WOMEN

A.A. Davlyatova - Samarkand State Medical University

Resume

The goal is to study the mechanisms of immunosuppression caused by sepsis and identify biomarkers that identify the state of weakened immunity in pregnant women with oral diseases. Factors contributing to the increasing prevalence of obstetric sepsis include advances in the use of immunomodulatory agents to treat a growing number of diseases and physiological immunosuppression during pregnancy.

Key words: obstetric sepsis, pregnancy, pathogenesis, immunosuppression, immunity, infection, phagocytosis.

First page

441

Last page

447

For citation:A.A. Davlyatova - THE ROLE OF ORAL DISEASES IN THE DEVELOPMENT OF POSTPARTUM SEPSIS IN PREGNANT WOMEN//New Day in Medicine 9(71)2024 441-447 https://newdayworldmedicine.com/en/new_day_medicine/9-71-2024

List of References

  1. Анисов Д. Э. и др. Итаконат регулирует продукцию цитокинов за счет подавления сукцинатдегидрогеназы в модели ЛПС-индуцированного воспаления //Медицинская иммунология. 2023;25(3):477-482.
  2. Интенсивная терапия сепсиса, септического шока в акушерстве. /Национальный клинический протокол. Ташкент, 2021
  3. Насирова З.А., Негмаджанов Б.Б. Влияние интраоперационной внутриматочной контрацепции на состояние гуморального иммунитета //Журнал репродуктивного здоровья и уро-нефрологических исследований, 2020;1(2):66-69.
  4. Насирова З.А., Агабабян Л.Р. Kesar kesishdan keyin ishlatiladigan kontrasepsiya vositalari va ularning immunitetga ta'siri (adabiyotlar tahlili) //Журнал Репродуктивного Здоровья и Уро-Нефрологических Исследований. 2020;1(2):27-32.
  5. Смирнова Т.Л., Портнова Е.В., Сергеева В.Е. Иммунитет и беременность //Вестник Чувашского университета. 2009;2:79-85.
  6. Aubron C, Berteau F, Sparrow RL. 2019. Intravenous immunoglobulin for adjunctive treatment of severe infections in ICUs. Curr. Opin. Crit. Care 2019;25:417-22.
  7. Burke J.D., Young H.A. 2019. IFN-γ: a cytokine at the right time, is in the right place. //Semin. Immunol. 2019;43:101-280
  8. Cui J, Wei X, Lv H, Li Y, Li P, et al. 2019. The clinical efficacy of intravenous IgM-enriched im- munoglobulin (pentaglobin) in sepsis or septic shock: a meta-analysis with trial sequential analysis. //Ann. Intensive Care 2019;9:27.
  9. de Roquetaillade C, Monneret G, Gossez M, Venet F. 2018. IL-7 and its beneficial role in sepsis-induced T lymphocyte dysfunction. //Crit. Rev. Immunol. 2018;38:433-51.
  10. Domínguez-Andrés J, Novakovic B, Li Y, Scicluna BP, Gresnigt MS, et al. 2019. The itaconate pathway is a central regulatory node linking innate immune tolerance and trained immunity. //Cell Metab. 2019;29:211-20.
  11. Dominari A, Hathaway D III, Pandav K, Matos W, Biswas S, et al. 2020. Thymosin alpha 1: a compre- hensive review of the literature. //World J. Virol. 2020;9:67-78.
  12. Domínguez-Andrés J, Novakovic B, Li Y, Scicluna BP, Gresnigt MS, et al. 2019. The itaconate pathway is a central regulatory node linking innate immune tolerance and trained immunity. //Cell Metab. 2019;29:211-2015.
  13. Francois B, Jeannet R, Daix T, Walton AH, Shotwell MS, et al. 2018. Interleukin-7 restores lymphocytes in septic shock: the IRIS-7 randomized clinical trial. //JCI Insight 2018;3(5):e98960
  14. Gustave CA, Gossez M, Demaret J, Rimmele T, Lepape A, et al. 2018. Septic shock shapes B cell response toward an exhausted-like/immunoregulatory profile in patients. //J. Immunol. 2018;200:2418–25
  15. Heming N, Sivanandamoorthy S, Meng P, Bounab R, Annane D. 2018. Immune effects of corticosteroids in sepsis. //Front. Immunol. 2018;9:1736.
  16. Hotchkiss RS, Colston E, Yende S, Angus DC, Moldawer LL, et al. 2019. Immune checkpoint inhibition in sepsis: a Phase 1b randomized, placebo-controlled, single ascending dose study of antiprogrammed cell death-ligand 1 antibody (BMS-936559). //Crit. Care Med. 2019;47:632-42.

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