3 -5 (37) 2021 — Adambayev Z.I. Ismailova M.O. — ANALYSIS OF THE EFFECTIVENESS OF THE PROPOSED OPTIMIZED ANTICONVULSANT, ANTIVIRAL AND IMMUNOMODULATORY THERAPY

ANALYSIS OF THE EFFECTIVENESS OF THE PROPOSED OPTIMIZED ANTICONVULSANT, ANTIVIRAL AND IMMUNOMODULATORY THERAPY

Adambayev Z.I. Neurological Clinic “Global Med System

Ismailova M.O. Urgench branch of the Tashkent Medical Academy

Resume

In the Aral Sea region, due to environmental disasters, mortality and the general morbidity of the population are increasing, including an increase in the incidence of viral diseases with an increase in symptomatic epilepsy of viral etiology. This type of symptomatic epilepsy has characteristic clinical and electroencephalographic manifestations, which, if necessary, is taken into account in the diagnosis and treatment of epilepsy. Research objectives The aim of the study was to study clinical and electroencephalographic manifestations in patients with symptomatic epilepsy of viral etiology in the Aral Sea region. Materials and methods of research. 90 patients with symptomatic signs of viral epilepsy were examined. The age of the patients ranged from 14 to 60 years, the average age was 26.1 ± 1.9 years. Among the surveyed there were 50 (66.7%) men and 40 (33.3%) women. Patients were subjected to neurological, clinical and laboratory, electroencephalographic examinations. The obtained results were compared with the indicators of the control group (30 people), which consisted of practically healthy persons of the same sex and age. Correlation analysis and Student’s criterion were used in statistical processing of the results. Results and discussion. Neurological examination of patients revealed various neurological changes, namely: diffuse cerebral microsymptomatics (in 50%), discordant (in 33.3%), mild pyramidal insufficiency (in 16.7%), intracranial hypertension syndrome (in 11.1%).      The distribution of patients by the nature of seizures showed that the leading clinical seizures were generalized seizures in 61.1% of patients and patients with simple and complex partial seizures (in 38.9%). The frequency of partial seizures with secondary generalization was 44.4%. 27.8% of patients had polymorphic seizures (simple partial seizures in combination with absences or, in combination with primary generalized tonic-clonic seizures). Conclusion. Neurological symptoms of HCVE complicated by symptomatic epilepsy, in addition to various forms of epileptic seizures, were characterized by the presence of scattered microsymptomatics and mild changes in the nervous system in the form of cognitive impairment (95%), autonomic dysfunction (52%), mild motor disorders (20%), sensitive (15%) and cerebellar (15%) disorders.

Key words: symptomatic epilepsy in infectious diseases, electroencephalo-graphic studies, complications of herpes infections, cytomegalovirus infection, and incidence rate in the Aral Sea region

First page

13

Last page

17

For citation: Adambayev Z.I. Ismailova M.O. ANALYSIS OF THE EFFECTIVENESS OF THE PROPOSED OPTIMIZED ANTICONVULSANT, ANTIVIRAL AND IMMUNOMODULATORY THERAPY //New Day in Medicine 5(37)2021 13-17 https://cutt.ly/MTEBOhG

LIST OF REFERENCES:

1. Karlov V. A. Farmakorezistentnost’ i tolerantnost’ pri epilepsii. Epilepsiya. Pod red. N. G. Neznanova. SPb. -2010. –S. 730-741.
2. Kryzhanovskaya S.V., Shnayder N.A. Etiopatogenez khronizatsii porazheniya tsentral’noy nervnoy sistemy pri gerpeticheskoy infektsii // Vestnik Klinicheskoy bol’nitsy №51. – 2010. – T. III, №10. – S. 38-48.
3. Movchan V.N., Amonulloyev O.KH. Sravnitel’naya otsenka ekologicheskoy situatsii v priaral’ye i prikaspii (kazakhstan) // Mezhdunarodnyy zhurnal prikladnykh i fundamental’nykh issledovaniy. – 2016. – № 3-4. – S. 623-626;
4. Sovmestnaya programma OON «Ukrepleniye potentsiala zhizneustoychivosti naseleniya, postradavshego v rezul’tate krizisa Aral’skogo morya, posredstvom sozdaniya mnogopartnerskogo fonda po bezopasnosti cheloveka dlya regiona Priaral’ya». Novostnoy Byulleten’ za pervyy kvartal 2017 goda.
5. Ahmad A., Ramakrishna S., Meara J., Doran M. Autoimmune limbic encephalitis: a reversible form of rapidly progressive amnesia and seizures. J R Coll Physicians Edinb. – 2010. № 40. -Р.123-125.
6. Armangue T., Petit-Pedrol M., Dalmau J. Autoimmune Encephalitis in Children. J Child Neurol. – 2012. №.27: -Р.1460-1469.
7. Kennedy P.G.E., Chaudhuri A. Herpes simplex encephalitis // J. Neurol. Neurosurg. Psychiatry. – 2002. – Vol. 73. №3. – P. 237–238.
8. Mohanraj R., Brodie M. J. Pharmacological outcome in early diagnosed epilepsy. Epilepsy Behavior. – 2005. № 6. -С. 382-387.
9. Ramsay R. E., Rowan A. J.,Pryor F. M. Special considerations in treating the elderly patient with epilepsy.Neurology. – 2004. №62. –Р. 24-29.
10. Vezzani A., French J., Bartfai T., Baram T.Z. The role of inflammation in epilepsy // Nat. Rev. Neurol. – 2011 – Vol. 7. №1. – P. 31-40.
11. Yao K., Crawford J.R., Komaroff A.L. et al. Review part 2: Human herpesvirus-6 in central nervous system diseases // J. Med. Virol. – 2010. – Vol. 82. №10. – P. 1669-1678.