28 -10 (72) 2024 - Shodikulova G.Z., Xasanov O.G. - FEATURES OF CLINICAL, LABORATORY AND INSTRUMENTAL RESEARCH METHODS IN PATIENTS WITH OSTEOARTHRITIS OF THE HIP JOINT

FEATURES OF CLINICAL, LABORATORY AND INSTRUMENTAL RESEARCH METHODS IN PATIENTS WITH OSTEOARTHRITIS OF THE HIP JOINT

Shodikulova G.Z. - Samarkand State Medical University

Xasanov O.G. - Samarkand State Medical University

Resume

The reason why the disease of osteoarthritis of the hip joint is being studied in greater depth is that immune-inflammatory changes directly affect the development of pathology and the effectiveness of treatment. Pro-inflammatory cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-a) were increased in synovial fluids and tissues of Bebor osteoarthritis patients. Through these immune markers, articular cartilage degradation and bone remodeling occur. Thus, in-depth study of clinical and immunological features of hip osteoarthritis development opens new opportunities for early diagnosis and individualization of treatment, which increases the chances of slowing disease progression and improving the quality of life of patients.

Keywords: osteoarthritis of the hip joint, genetic properties, early diagnosis, treatment

First page

181

Last page

189

For citation:Shodikulova G.Z., Xasanov O.G. - FEATURES OF CLINICAL, LABORATORY AND INSTRUMENTAL RESEARCH METHODS IN PATIENTS WITH OSTEOARTHRITIS OF THE HIP JOINT//New Day in Medicine 10(72)2024 181-189 https://newdayworldmedicine.com/en/new_day_medicine/10-72-2024

List of References

1. Shodikulova G.Z., Vohidov J.J. Romatoid artrit diagnostikasi va davolash bo'yicha zamonaviy qarashlar (adabiyot sharhi) //The theory of recent scientific research in the field of pedagogy. – 2023;1(6):101-112.
2. Shodikulova G.Z., Vohidov J.J. Romatoid artrit uchun diagnostika va davolash usullarini optimallashtirish //The theory of recent scientific research in the field of pedagogy. 2023;1(6):56- 67.
3. Babamuradova Z. B., Shavazi N. N. Assessment of the efficacy and safety of biological agents in rheumatoid arthritis //Journal of Advanced Medical and Dental Sciences Research. 2021;9(6):26-31.
4. Avramescu C, Biciusca V, Daianu T et al. Cytokine panel and histopathological aspects in the systemic lupus erythematosus. //Rom J Morphol Embryol. 2010;51(4):633-40.
5. Clark KEN, Lopez H, Abdi BA. Multiplex cytokine analysis of dermal interstitial blister fluid defines local disease mechanisms in systemic sclerosis. //Arthritis Res Ther. 2015;17:73. doi: 10.1186/s13075- 015-0575-8
6. Denton C.P., Khanna D. Systemic sclerosis. //Lancet 2017;390:1685-1699.
7. Hinchcliff M, Huang CC, Wood TA, et al. Molecular signatures in skin associated with clinical improvement during mycophenolate treatment in systemic sclerosis. //J Invest Dermatol. 2013;133:1979-89. doi: 10.1038/jid.2013.130
8. Ritchlin C.T. The pathogenesis of psoriatic arthritis. //Surr Opin Rheumatol 2005;17:406-12.
9. Shodikulova G. Z., Pulatov U. S. Efficiency evaluation of treatments patients with rheumatoid arthritis by dependence of clinic course and genetic polymorphism of haptoglobins //Toshkent tibbiyot akademiyasi axborotnomasi. 2020;1:175-178.
10. Shodikulova G.Z. et al. The Correlation among Osteoporosis, Calcium-Phosphore Metabolism and Clinical Symptoms of Main Disease in Patients with Rheumatoid Arthritis //Annals of the Romanian Society for Cell Biology. 2021; S. 4185-4190.

    file

    download