81 -10 (72) 2024 - Saidov S.A., Juraeva G.B. - DYNAMIC MONITORING OF CHANGES IN EXPERIMENTAL ANIMALS USING A MODEL OF OSTEOPOROSIS AND METABOLIC SYNDROME

DYNAMIC MONITORING OF CHANGES IN EXPERIMENTAL ANIMALS USING A MODEL OF OSTEOPOROSIS AND METABOLIC SYNDROME

Saidov S.A. - Institute of Pharmaceutical Education and Research, Uzbekistan

Juraeva G.B. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Mavlonov A.A. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Boboeva R.R. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Metabolic syndrome is a very common clinical condition, affecting on average one in five adults in developed countries. Dietary models are the most adequate from the point of view of the etiology and mechanisms of development of metabolic diseases in humans. Nutrition affects the regulation of metabolism throughout the body through hormonal, carbohydrate and lipid metabolism. There are several definitions of multiple sclerosis, but most of them include conditions such as abdominal obesity, high-density lipoproteins, high cholesterol, triglycerides, hypertension, etc. The goal - determine bone trabecular changes in an experimental model of metabolic syndrome and osteoporosis in rabbits using a clinically available MSCT method (multislice computed tomography (MSCT) device (SIMENS). Material and research methods. The experimental studies were conducted on 30 male and female rabbits weighing 2.0-2.5 kg. The animals were kept in standard vivarium conditions with a natural 12-hour light and dark cycle and an air temperature of 20±200. Body measurements were taken before and after the introduction of the experimental diet. Bone tissue in all rabbits was examined by MSCT in axial, proximal (frontal), sagittal sections. Pearson's correlation coefficient was used to determine the correlation between the conductivity parameter and bone mineral density. Repeated measurements were used to analyze bone tissue changes over time in each group in the rabbit model with osteoporosis at different time points according to the Hounsfield scale. Results: MSCT showed that changes were predominantly observed in the proximal and distal parts of the bone, in the ribs, in the heart and liver area. Conclusions: Animal models are powerful tools to understand the mechanisms underlying pathological processes such as metabolic syndrome. To date, few diet-based rabbit models of metabolic syndrome have been used using high-fat diets and most importantly, the characterization of the different components of metabolic syndrome have not been described in detail. To develop and characterize a diet-based experimental rabbit model of metabolic syndrome that will allow further study of cardiovascular remodeling and arrhythmogenesis. This study assessed in vivo bone plate signaling changes, meniscus changes, longitudinal changes and osteophytes in rabbits.

Keywords: metabolic syndrome, osteoporosis

First page

448

Last page

452

For citation:Saidov S.A., Juraeva G.B., Mavlonov A.A., Boboeva R.R. - DYNAMIC MONITORING OF CHANGES IN EXPERIMENTAL ANIMALS USING A MODEL OF OSTEOPOROSIS AND METABOLIC SYNDROME//New Day in Medicine 10(72)2024 448-452 https://newdayworldmedicine.com/en/new_day_medicine/10-72-2024

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