• Home
  • NEW DAY MEDICINE
  • 11 (73) 2024
  • 45 -11 (73) 2024 - Urokov. Sh.T., Abidov U.O. - GASTROINTESTINAL BLEEDING IN PATIENTS WITH LIVER CIRRHOSIS AND THE SIGNIFICANCE OF BLEEDING FROM GASTRODUODENAL ULCERS

45 -11 (73) 2024 - Urokov. Sh.T., Abidov U.O. - GASTROINTESTINAL BLEEDING IN PATIENTS WITH LIVER CIRRHOSIS AND THE SIGNIFICANCE OF BLEEDING FROM GASTRODUODENAL ULCERS

GASTROINTESTINAL BLEEDING IN PATIENTS WITH LIVER CIRRHOSIS AND THE SIGNIFICANCE OF BLEEDING FROM GASTRODUODENAL ULCERS

Urokov. Sh.T. - Bukhara State Medical Institute named after Abu Ali ibn Sina, Bukhara branch of the Republican Scientific Center for Emergency Medical Care Uzbekistan

Abidov U.O - Bukhara State Medical Institute named after Abu Ali ibn Sina, Bukhara branch of the Republican Scientific Center for Emergency Medical Care Uzbekistan

Salomov N.I. - Bukhara State Medical Institute named after Abu Ali ibn Sina, Bukhara branch of the Republican Scientific Center for Emergency Medical Care Uzbekistan

Resume

Liver cirrhosis (LC) is a chronic condition that causes significant changes in the body, including circulatory disturbances, particularly in the portal system, and impaired liver function. One of the most dangerous complications of LC is upper gastrointestinal (GI) bleeding, which can result from several factors such as portal hypertension, esophageal varices, gastropathy, and gastric or duodenal ulcers. In 40-45% of patients with complicated gastroduodenal ulcer (GDU) bleeding on the background of LC, typical ulcer symptoms are absent. Special imaging techniques, including MRI, MSCT, and elastography, revealed previously undiagnosed cirrhosis in 3-6% of patients who had experienced GDU bleeding. Even when bleeding from esophageal varices (EV) was identified, 4.6% of patients were found to have GDU bleeding as a second source upon further examination. The severity of GDU bleeding in 45-53% of patients with LC was due to coagulopathy, leading to a severe or extremely severe course of the disease. Etiological factors contributing to GDU bleeding in LC patients included viral hepatitis, as well as alcoholic cirrhosis in 32% of cases, and alcohol abuse in 45% of patients. More than half of the GDUs were located in various parts of the stomach.

Keywords: liver cirrhosis, gastroduodenal ulcer bleeding, coagulopathy, alcohol abuse, diagnosis, complications.

First page

248

Last page

255

For citation:Urokov. Sh.T., Abidov U.O., Salomov N.I. - GASTROINTESTINAL BLEEDING IN PATIENTS WITH LIVER CIRRHOSIS AND THE SIGNIFICANCE OF BLEEDING FROM GASTRODUODENAL ULCERS//New Day in Medicine 11(73)2024 248-255 https://https://newdayworldmedicine.com/en/new_day_medicine/11-73-2024

List of References

  1. Afessa B, Kubilis PS. Upper gastrointestinal bleeding in patients with hepatic cirrhosis: clinical course and mortality prediction. //Am J Gastroenterol 2000;95:484-489.
  2. Ahmed Gado, Basel Ebeid, Anthony Axon, Prevalence and outcome of peptic ulcer bleeding in patients with liver cirrhosis, //Alexandria Journal of Medicine, 2014;50(2):143-148.
  3. Augustin S, González A, Genescà J. Acute esophageal variceal bleeding: Current strategies and new perspectives. //World J Hepatol. 2016;8(9):293-305. DOI: 10.4254/wjh. v8. i9.293.
  4. Baveno VI Consensus Workshop. Methodology of diagnosis and therapy in portal hypertension. //J Hepatol. 2015;63(3):743-752. DOI: 10.1016/j.jhep.2015.05.022.
  5. D’Amico G, De Franchis R, Cooperative Study Group. Upper digestive bleeding in cirrhosis. Post-therapeutic outcome and prognostic indicators. //Hepatology. 2003;38:599-612.
  6. D’Amico G, De Franchis R. Upper digestive bleeding in cirrhosis. Post-therapeutic outcome and prognostic indicators. //Hepatology 2003;38:599-612.
  7. Liu Y., Maeda A., Anvari M., Jackson T., Okrainec A. Marginal ulceration following Roux-en-Y gastric bypass: risk factors for ulcer development, recurrence and need for revisional surgery //Surg Endosc. 2021;35(5):2347-2353.
  8. Holland-Bill L, Christiansen CF, Gammelager H, Mortensen RN, Pedersen L, Sørensen HT. Chronic liver disease and 90-day mortality in 21 359 patients following peptic ulcer bleeding a Nationwide Cohort Study. //Aliment Pharmacol Ther 2015;41:564-572.
  9. Hsu YC, Lin JT, Chen TT, Wu MS, Wu CY. Long-term risk of recurrent peptic ulcer bleeding in patients with liver cirrhosis: a 10-year nationwide cohort study. //Hepatology 2012;56:698-750.
  10. Reiberger T, Mandorfer M. Beta adrenergic blockade and decompensated cirrhosis. //J Hepatol. 2017;66(4):849-859. DOI: 10.1016/j.jhep.2016.11.003.
  11. Tripathi D, Stanley AJ, Hayes PC, et al. UK guidelines on the management of variceal haemorrhage in cirrhotic patients. //Gut. 2015;64(11):1680-1704. DOI: 10.1136/gutjnl-2015-309262.

    file

    download