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  • 90 -11 (73) 2024 - Kurbanov B.B., Djamilova H.A. - STUDY OF THE ROLE OF THE ENDOTHELIAL SYSTEM REGULATOR GENE IN THE DEVELOPMENT OF HYPERTENSION DURING PREGNANCY

90 -11 (73) 2024 - Kurbanov B.B., Djamilova H.A. - STUDY OF THE ROLE OF THE ENDOTHELIAL SYSTEM REGULATOR GENE IN THE DEVELOPMENT OF HYPERTENSION DURING PREGNANCY

STUDY OF THE ROLE OF THE ENDOTHELIAL SYSTEM REGULATOR GENE IN THE DEVELOPMENT OF HYPERTENSION DURING PREGNANCY

Kurbanov B.B. - Tashkent Pediatric Medical Institute

Djamilova H.A. - Tashkent Pediatric Medical Institute

Resume

The aim of the work: was to study the C-786T polymorphism in the NOS3 gene in the development of hypertensive conditions during pregnancy. Materials and methods of the study: To achieve the set goal and objectives, we conducted a study of 104 pregnant women admitted to inpatient treatment in the II-III trimester, who were divided into three groups: The first group of 43 pregnant women with severe preeclampsia, the second group of 33 pregnant women with mild preeclampsia, the third group - 28 women with gestational hypertension. The control group - 107 pregnant women. Results: The C/C genotype of the C-786T polymorphism of the NOS3 gene was statistically significantly less common - in 51.9% of cases - in the main group (χ2 = 4.55; p = 0.04; RR = 0.78; 95% CI: 0.46-1.33; OR = 0.55; 95% CI: 0.32-0.95), compared to 66.4% in the control group, which indicates its non-protective properties. Conclusions: the obtained results of our study allow us to conclude that the unfavorable genotypic variants of the C-786T polymorphism of the NOS3 gene make a significant contribution to the development of the disease.

Key words: hypertension, preeclampsia, gene.

First page

526

Last page

531

For citation:Kurbanov B.B., Djamilova H.A. - STUDY OF THE ROLE OF THE ENDOTHELIAL SYSTEM REGULATOR GENE IN THE DEVELOPMENT OF HYPERTENSION DURING PREGNANCY//New Day in Medicine 11(73)2024 526-531 https://https://newdayworldmedicine.com/en/new_day_medicine/11-73-2024

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