24 -5 (36) 2021 — Lyubov M. Makarieva, Victor A. Akulinin — MORPHOMETRIC ANALYSIS OF MANIFESTATIONS EDEMA-SWELLING OF THE HIPPOCAMPAL FORMATION AFTER LIGGING OF THE COMMON CAROTID ARTERIES

MORPHOMETRIC ANALYSIS OF MANIFESTATIONS EDEMA-SWELLING OF THE HIPPOCAMPAL FORMATION AFTER LIGGING OF THE COMMON CAROTID ARTERIES

Lyubov M. Makarieva, Omsk State Medical University, Ministry of Health of Russia

Victor A. Akulinin, Omsk State Medical University, Ministry of Health of Russia

Sergei S. Stepanov, Omsk State Medical University, Ministry of Health of Russia

Anastasia Yu. Shoronova, Omsk State Medical University, Ministry of Health of Russia

Dmitry B. Avdeev, Omsk State Medical University, Ministry of Health of Russia

Ella V. Martynova, Omsk State Medical University, Ministry of Health of Russia

Mikhail S. Korzhuk. Omsk State Medical University, Ministry of Health of Russia

Resume

The aim is to study the structural changes of neurons and glia, to give a morphometric characteristic of the manifestations of edema-swelling of the hippocampal formation in white rats after 1, 3, 7, 14 and 30 days in normal conditions and in dynamics after bilateral ligation of the common carotid arteries. Structural and functional restoration of the hippocampus occurs against the background of hyperhydration of the neuropil, perineuronal and perivascular spaces (legs of astrocytes). The extreme degree of variation of these manifestations is observed on days 1-14, which indicates dysfunction of astrocytes as a result of excessive edema of their processes. Manifestations of overhydration in the hippocampal formation were observed throughout the study period (30 days).

Key words: ischemia, hippocampus, dentate gyrus, morphometry, rats.

First page

84

Last page

86

For citation: Lyubov M. Makarieva, Victor A. Akulinin, Sergei S. Stepanov, Anastasia Yu. Shoronova, Dmitry B. Avdeev, Ella V. Martynova, Mikhail S. Korzhuk. MORPHOMETRIC ANALYSIS OF MANIFESTATIONS EDEMA-SWELLING OF THE HIPPOCAMPAL FORMATION AFTER LIGGING OF THE COMMON CAROTID ARTERIES //New Day in Medicine 5(37)2021 84-86 https://cutt.ly/nTTqpni

LIST OF REFERENCES:

1. Eszter F., Paul G.M. Luiten, Ferenc B. Permanent, bilateral common carotid artery occlusion in the rat: A model for chronic cerebral hypoperfusion-related neurodegenerative diseases // Brain research reviews. – 2007. –Т.54, №1. – С.162-180.
2. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 5th ed. San Diego: Elsevier Academic Press; 2005
3. Herbert A.D., Carr A.M., Hoffmann E. FinDGoci: A focus detection algorithm with automated parameter training that closely matches human assignments reduces human inconsistencies and increases speed of analysis. PLoS 1. 2014: 9(12): e114749.
4. Avdeyev D.B., Akulinin V.A., Gorbunova A.V., Stepanov S.S., Shoronova A.Yu., Makar’yeva L.M., Kucheruk A.N., Korzhuk M.S. Otok-nabukhaniye kak standartnaya dozozavisimaya reaktsiya zubchatoy ​​izviliny gippokampal’noy formy na ostruyu ishemiyu // Zhurnal anatomii i gistopatologii. – 2021. – T.10, № 3. – S.15-26.