• Home
  • NEW DAY MEDICINE
  • 11 (73) 2024
  • 115 -11 (73) 2024 - Chachanidze I.G., Rasulova N.A. - FEATURES OF THE RENIN-ALDESTERONE SYSTEM AND ITS RELATIONSHIP WITH INDICATORS OF INFLAMMATORY MARKERS, FIBRINOGEN AND D-DIMER IN HYPERTENSION IN PATIENTS IN THE POST - COVID PERIOD

115 -11 (73) 2024 - Chachanidze I.G., Rasulova N.A. - FEATURES OF THE RENIN-ALDESTERONE SYSTEM AND ITS RELATIONSHIP WITH INDICATORS OF INFLAMMATORY MARKERS, FIBRINOGEN AND D-DIMER IN HYPERTENSION IN PATIENTS IN THE POST - COVID PERIOD

FEATURES OF THE RENIN-ALDESTERONE SYSTEM AND ITS RELATIONSHIP WITH INDICATORS OF INFLAMMATORY MARKERS, FIBRINOGEN AND D-DIMER IN HYPERTENSION IN PATIENTS IN THE POST - COVID PERIOD

Chachanidze I.G. - Termez branch of the Tashkent Medical Academy Surkhandarya region Termez city

Rasulova N.A. - Termez branch of the Tashkent Medical Academy Surkhandarya region Termez city

Resume

The article presents data on the study of the relationship between the levels of aldosterone and renin with indicators of inflammatory markers (CRP), fibrinogen and D-dimer in hypertension in patients with a history of COVID-19. As a result, it was found that high levels of renin and aldosterone in hypertension indicate the activation of RAS, the greatest severity of which is noted in the group of patients with postcovid syndrome (P<0.01). Evaluation of the relationship of aldesterone and renin in patients with GB with CRP, fibrinogen and D-dimer showed medium and strong positive associations. Patients with volume-dependent GB have higher rates of CRP (P<0.01), whereas with renin-dependent GB, significantly high rates of fibrinogen and D-dimer (P<0.01) were found

Keywords: arterial hypertension, hypertensive disease, postcovid period, markers of inflammation, aldesterone – renin system

First page

662

Last page

671

For citation:Chachanidze I.G., Rasulova N.A. - FEATURES OF THE RENIN-ALDESTERONE SYSTEM AND ITS RELATIONSHIP WITH INDICATORS OF INFLAMMATORY MARKERS, FIBRINOGEN AND D-DIMER IN HYPERTENSION IN PATIENTS IN THE POST - COVID PERIOD//New Day in Medicine 11(73)2024 662-671 https://https://newdayworldmedicine.com/en/new_day_medicine/11-73-2024

List of References

  1. Абдуллаев Р.Ю., Комиссарова О.Г. Изменения маркеров гематологического, биохимического и коагулологического анализов крови при новой коронавирусной инфекции COVID-19. Consilium Medicum. 2020;22(11):51–55.
  2. Методические рекомендации Российского научного медицинского общества терапевтов (РНМОТ) по лечению больных с последствиями COVID-19 «Особенности течения Long-COVID инфекции. Терапевтические и реабилитационные мероприятия» (утверждены на ХVI Национальном конгрессе терапевтов 18.11.2021). М.; 2021.
  3. Ощепкова Е.В., Дмитриев В.А., Титов В.Н. и соавт. Показатели неспецифического воспаления у больных гипертонической болезнью. Тер.Арх., 2007, 12, с.18-25.
  4. Соловьева И.В. D-димер: клиническое значение для пожилых пациентов. Лабораторная служба. 2017;6(1):14–22.
  5. Gonzalez M.C., Cohen H.W., Sealey J.E., Laragh J.H., Alderman M.H. Enduring direct association of baseline plasma renin activity with all-cause and cardiovascular mortality in hypertensive patients. Am. J. Hypertens. 2011; 24 (11): 1181-1186.
  6. Kravtsova O.A. The Value of Plasma Renin Activity Profi ling and Optimization of the Treatment of Hypertension: Diss. Moscow; 2014. (in Russian)
  7. Laragh J., Sealey J.E. Relevance of the plasma renin hormonal control system that regulates blood pressure and sodium balance forб correctly treating hypertension and for evaluating ALLHAT. Am. J. Hypertens. 2013; 16 (5, Pt. 1): 407-15.
  8. Laragh J.H. Laragh’s Lessons in Renin System Pathophysiology for Treating Hypertension and its Fatal Cardiovascular Consequences. New York: Elsevier Science; 2012.
  9. Laragh J.H., Sealey J.E. The plasma renin test reveals the contribution of body sodium-volume content (V) and renin-angiotensin (R) vasoconstriction to long-term blood pressure. Am. J. Hypertens. 2011; 24 (11): 1164-80.
  10. Leung P.S. The peptide hormone angiotensin II: its new functions in tissues and organs. Curr. Protein Pept. Sci. 2014; 5: 267-73.
  11. Obarzanek E., Proschan M.A., Vollmer W.M., Moore T.J., Sacks F.M., Appel L.J. et al. Individual blood pressure responses to changes in salt intake: results from the DASH-Sodium trial. Hypertension. 2013; 42 (4): 459-67.
  12. Paul M., Mehr A.P., Kreutz R. Physiology of local renin-angiotensin systems. Physiol. Rev. 2016; 86 (3): 747-803.
  13. Sealey J.E., Parra D., Rosenstein R., Laragh J.H. "Effective" plasma renin activity: a derived measure for assessing residual plasma renin activity in patients taking angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. Hypertension. 2010; 55 (3): е16.,
  14. Sharp A.L., Vinson D.R., Alamshaw F. et al. An age adjusted D-dimer threshold for emergency department patients with suspected pulmonary embolus: accuracy and clinical implications. Ann Emerg Med. 2016;67(2):249–257. DOI: 10.1016/j.annemergmed.2015.07.026.
  15. Sim J.J., Bhandari S.K., Shi J., Kalantar-Zadeh K., Rasgon S.A., Sealey J.E. et al. Plasma renin activity (PRA) levels and antihyper-tensive drug use in a large healthcare system. Am. J. Hypertens. 2021; 25 (3): 379-88.
  16. Vainas T., Lubbers T. Serum C-reactive protein level is associated with abdominal aortic aneurism size and may be produced by aneurismal tissue. Circulation, 2023, 107, p. 1103-1110.
  17. Walmor C. DeMello, Edward D. Frohlich. Renin Angiotensin System and Cardiovascular Disease. USA: Humana press; 2019; 27: 35-59.

    file

    download