117 -11 (73) 2024 - Yakubov М.Z. - MORPHOLOGICAL CRITERIA FOR COLPOPOIESIS OF THE ARTIFICIAL VAGINA

MORPHOLOGICAL CRITERIA FOR COLPOPOIESIS OF THE ARTIFICIAL VAGINA

Yakubov М.Z. - Samarkand State Medical University Uzbekistan

Resume

The study showed that patients with Mayer-Rokitansky-Kuster-Hauser syndrome who underwent surgery to create a neovagina from a segment of the sigmoid colon have pronounced structural and functional changes in the mucous membrane. These changes include a phase process that goes through three stages, and lead to dysplasia of the intestinal epithelium. In the first years of observation, hyperplasia of goblet cells and increased mucus production are noted, which gradually decrease, and after 8-10 years the epithelium acquires a multilayer structure, losing its permeability. In the process of neovaginal adaptation, a decrease in the number of crypts, increased fibrosis and the occurrence of dysplastic changes in epithelial cells, including the appearance of dual-core enterocytes and cells of a "mixed phenotype", were revealed. Since the adaptation process is accompanied by long-term dysplastic changes, this requires oncological monitoring of the condition of the neovagina later

Keywords: neovagina, mucous membrane, Mayer-Rokitansky-Kuster-Hauser syndrome, histology

First page

675

Last page

681

For citation:Yakubov М.Z. - MORPHOLOGICAL CRITERIA FOR COLPOPOIESIS OF THE ARTIFICIAL VAGINA//New Day in Medicine 11(73)2024 675-681 https://https://newdayworldmedicine.com/en/new_day_medicine/11-73-2024

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