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  • 148 -11 (73) 2024 - Zufarova Sh.A., Eshdavlatov I.E. - PATHOGENETIC MECHANISMS OF "EPITHELIAL-MESENCHYMAL TRANSITIONS" IN THE DEVELOPMENT OF ADHESIVE DISEASE DURING SURGICAL INTERVENTIONS IN GYNECOLOGY

148 -11 (73) 2024 - Zufarova Sh.A., Eshdavlatov I.E. - PATHOGENETIC MECHANISMS OF "EPITHELIAL-MESENCHYMAL TRANSITIONS" IN THE DEVELOPMENT OF ADHESIVE DISEASE DURING SURGICAL INTERVENTIONS IN GYNECOLOGY

PATHOGENETIC MECHANISMS OF "EPITHELIAL-MESENCHYMAL TRANSITIONS" IN THE DEVELOPMENT OF ADHESIVE DISEASE DURING SURGICAL INTERVENTIONS IN GYNECOLOGY

Zufarova Sh.A. - Тashkent Pediatric Medical Institute

Eshdavlatov I.E. - Samarkand State Medical University of Uzbekistan

Resume

The article presents data on the participation of "epithelial-mesenchymal transitions" in the pathogenetic mechanism of the development of the adhesive process in women who underwent gynecological surgical interventions. The pathogenetic mechanism of the participation of matrix metalloproteinases-2 and 9 and tumor necrosis factor-a in the development of the adhesive process in women who underwent gynecological surgical interventions has been proven. Their high indices indicate a destructive effect on the extracellular matrix, creating conditions for the development of the adhesive process due to the growth of fibrous tissue. The range of levels of MMP-2 >400 pg/ml, MMP-9 >350 pg/ml and TNF-α >45 pg/ml was established in determining the risk of adhesive processes after gynecological operations.

Key words: women, adhesive disease, pathogenesis, matrix metalloproteinases, tumor necrosis factor.

First page

845

Last page

850

For citation:Zufarova Sh.A., Eshdavlatov I.E. - PATHOGENETIC MECHANISMS OF "EPITHELIAL-MESENCHYMAL TRANSITIONS" IN THE DEVELOPMENT OF ADHESIVE DISEASE DURING SURGICAL INTERVENTIONS IN GYNECOLOGY//New Day in Medicine 11(73)2024 845-850 https://https://newdayworldmedicine.com/en/new_day_medicine/11-73-2024

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