46 -12 (74) 2024 - Rakhimov B.A. - THE INFLUENCE OF THE CHOICE OF ANESTHESIA METHOD ON THE IMMUNE RESPONSE OF PATIENTS WHO UNDERWENT RADICAL SURGERY FOR BREAST CANCER
THE INFLUENCE OF THE CHOICE OF ANESTHESIA METHOD ON THE IMMUNE RESPONSE OF PATIENTS WHO UNDERWENT RADICAL SURGERY FOR BREAST CANCER
Rakhimov B.A. - Bukhara State Medical Institute named after Abu Ali ibn Sina
Resume
The aim of this study was to determine the impact of anesthesia techniques on selected parameters of patient immunity considering the evidence of relationship between the anesthesia methods and immune status and, consequently, the incidence of cancer recurrence. The patients who underwent breast cancer surgery under TIVA had lower blood leukocyte counts and levels of MMP-9, which is involved in the remodeling of extracellular matrix, compared with thos operated on under IA, suggesting that the anesthesia method may have an impact on the immunity of breast cancer patients
Keywords: anesthesia; breast cancer; surgery; immunomodulation; inhaled anesthesia; intravenous anesthesia
First page
246
Last page
250
For citation:Rakhimov B.A. - THE INFLUENCE OF THE CHOICE OF ANESTHESIA METHOD ON THE IMMUNE RESPONSE OF PATIENTS WHO UNDERWENT RADICAL SURGERY FOR BREAST CANCER//New Day in Medicine 12(74)2024 246-250 https://https://newdayworldmedicine.com/en/new_day_medicine/12-74-2024
List of References
- Tsimberidou A.M., Fountzilas E., Nikanjam M., Kurzrock R. Review of precision cancer medicine: evolution of the treatment paradigm. Cancer Treat Rev. 2020;86:102019.
- Zaimy M.A., Saffarzadeh N., Mohammadi A., Pourghadamyari H., Izadi P., Sarli A., Moghaddam LK., Paschepari SR., Azizi H., Torkamandi S., Tavakkoly-Bazzaz J. New methods in the diagnosis of cancer and gene therapy of cancer based on nanoparticles. Cancer Gene Ther. 2017;24(6):233-243. DOI: 10.1038/cgt.2017.16. PMID: 28574057.
- Soltanizadeh S., Degett T.H., Gogenur I. Outcomes of cancer surgery after inhalational and intravenous anesthesia: a systematic review. //J Clin Anesth. 2017;42:19-25. DOI: 10.1016/j.jclinane.2017.08.001. PMID: 28797751.
- Snyder G.L., Greenberg S. Effect of anaesthetic technique and other perioperative factors on cancer recurrence. //Br J Anaesth. 2010;105(2):106-115. DOI: 10.1093/bja/aeq164. PMID: 20627881.
- Adams J.M., Cory S. The Bcl-2 apoptotic switch in cancer development and therapy. //Oncogene. 2007;26(9):1324-1337. DOI: 10.1038/sj.onc. 1210220. PMID: 17322918.
- Jaura A.I., Flood G., Gallagher H.C., Buggy D.J. Differential effects of serum from patients administered distinct anaesthetic techniques on apoptosis in breast cancer cells in vitro: a pilot study. //Br J Anaesth. 2014;113 (Suppl 1): 163-167. DOI: 10.1093/bja/aet581. PMID: 25009197.
- Yan T., Zhang G-H., Wang B-N., Sun L., Zheng H. Effects of propofol/remifentanil-based total intravenous anesthesia versus sevoflurane-based inhalational anesthesia on the release of VEGF-C and TGF-β and prognosis after breast cancer surgery: a prospective, randomized and controlled study. //BMC Anesthesiol. 2018;18(1):131. DOI: 10.1186/s12871-018-0588-3. PMID: 30243294.
- Likhvantsev V., Yadgarov M., Di Piazza M., Kadantseva K. Inhalation vs total intravenous anesthesia in cancer surgery: where is the «pendulum» now? (meta-analysis and review). General Reanimatology. 2020;16(6):91-104. DOI: 10.15360/1813-9779-2020-6-91-104.
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