76 -12 (74) 2024 - Samadova Sh.I. - CHANGES IN BIOCHEMICAL INDICATORS DURING THE DEVELOPMENT OF AL-VEOLITHS

CHANGES IN BIOCHEMICAL INDICATORS DURING THE DEVELOPMENT OF AL-VEOLITHS

Samadova Sh.I. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

In this work, we study the content of soluble cell adhesion molecules that mediate the initial and final stages of leukocyte migration to the site of inflammation (sP-selectin and sVCAM-1), as well as some previously unstudied factors associated with their level, in blood serum of patients with alveo-litis. 48 patients aged from 20 to 55 years were examined, with an average age of 35.6±3.0 (M±o). The diagnosis was made on the basis of a comprehensive examination, which included studying the den-tal status and immunological testing of all patients with clinical detection of alveolitis. Data analysis was performed using the application package “STA-TISTICA v. 6.0" for Windows XP Descriptive statistics of the trait included the arithmetic mean (M), minimum and maximum values, median (Me) and interquartile range [Q25-Q75]. When comparing the results obtained, the Mann-Whitney test was used due to the inconsistency of the analyzed data with the law of normal distribution. Rela-tionships between characteristics were studied using Spearman correlation analysis (R). Differences were considered statistically significant at p < 0.05.

Key words: alveolitis, leukocyte. immunological testing

First page

391

Last page

394

For citation:Samadova Sh.I. - CHANGES IN BIOCHEMICAL INDICATORS DURING THE DEVELOPMENT OF AL-VEOLITHS//New Day in Medicine 12(74)2024 391-394 https://https://newdayworldmedicine.com/en/new_day_medicine/12-74-2024

List of References

  1. Баранов А. А., Потапов А. С., Цимбалова Е. Г. Современные технологии диагностики и лечения воспалительных заболеваний кишечника у детей. Вестн. РАМН. 2011; 6: 36-41.
  2. Козлов И.Г., Горлина Н.К., Чередеев А.Н. Рецепторы контактного взаимодействия. Им-мунология., 1995, 6, 14-25.
  3. Новиков В. В., Караулов А. В., Барышников А. Ю. Раствори¬мые формы мембранных ан-тигенов клеток иммунной системы. Иммунология. 2007; 4: 249-253.
  4. Пинегин Б. В., Маянский А. Н. Нейтрофилы: структура и функ¬ция. Иммунология. 2007; 6: 374-382.
  5. Маянский Д. Н. Лекции по клинической патологии. 2008. С. 15-78.
  6. Papadakis K.A., Targan S. R. Role of cytokines in the patho¬genesis of inflammatory bowel disease. Ann. Rev. Med. 2000; 51: 289-298.
  7. van Assche G., Rutgeerts FI Antiandhesion molecule therapy in inflammatory bowel disease. Inflamm. Bowel Dis. 2002; 8: 291-300.
  8. Mac Donald T. T., Monteleone G. Adaptive immunity: Effector and inhibitory cytokine pathways in gut inflammation. In: S. R. Targan, F. Shanahan, L. C. Karp (eds.). Inflammato-ry bowel disease. Translating basic science into clinical practice. Chichester: Wiley- Blackwell. 2010. P. 82-91.
  9. Song W. B., Lv Yn., Zhang Z. S., Li Yn., Xiao L. P., Yu X. P., Wang Y. Y., Ji FI. L., Ma L. Soluble intercellular adhesion molecule-1, D-lactate and diamine oxidase in patients with in-flammatory bowel disease. World J. Gastroenterol. 2009; 15 (31): 3916-3919.

    file

    download