102 -12 (74) 2024 - Ruziyev Z.M. - FEATURES OF DISORDERS OF THE BLOOD COAGULATION SYSTEM IN PATIENTS WITH ACUTE LEUKEMIA

FEATURES OF DISORDERS OF THE BLOOD COAGULATION SYSTEM IN PATIENTS WITH ACUTE LEUKEMIA

Ruziyev Z.M. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Blood coagulation is a multi-stage process that begins in the area of damaged endothelium, where some biochemical processes associated with the tissue factor occur, which triggers the second, autowave stage of clot growth, where mainly the reactions of the internal coagulation pathway work, and, finally, the growth process stops as a result of the formation of a thrombus from fibrin and extremely activated platelets on the damaged surface. Microvesicles play a huge role during the second and third stages. The fact is that the rate-determining stages at these two stages are the formation of procoagulant complexes of active blood coagulation factors - X, IX and II, with their cofactors, and the anticoagulant complex - protein C with thrombomodulin, which stops the spread of coagulation outside the damaged area. Phospholipid surfaces with a special set of charges are necessary for the assembly of all these complexes

Keywords: Blood clotting, blood clotting factor, hypercoagulation, thrombosis, Hemorrhagic syndrome

First page

533

Last page

536

For citation:Ruziyev Z.M. - FEATURES OF DISORDERS OF THE BLOOD COAGULATION SYSTEM IN PATIENTS WITH ACUTE LEUKEMIA//New Day in Medicine 12(74)2024 533-536 https://https://newdayworldmedicine.com/en/new_day_medicine/12-74-2024

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