146 -12 (74) 2024 - Artykova M.A., Avezov S.K. - EFFECTIVENESS OF THE NEUROPROTECTOR CHOLINE ALPHOSCERATE IN THE TREATMENT OF CHILDREN WITH TRAUMATIC BRAIN INJURY

EFFECTIVENESS OF THE NEUROPROTECTOR CHOLINE ALPHOSCERATE IN THE TREATMENT OF CHILDREN WITH TRAUMATIC BRAIN INJURY

Artykova M.A. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Avezov S.K. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Relevance. Traumatic brain injury (TBI) is a significant cause of high rates of nervous system diseases (19.5%) and mental disorders (14.5%), particularly among childhood disabilities. The nature of neurological deficits depends on the severity of the trauma and the post-traumatic period. Neurological deficits and cognitive impairments in children with TBI often lead to persistent disabilities. A complex relationship between the pathogenetic processes in the central nervous system (CNS) and TBI has been identified. However, studies of TBI pathogenesis and the development of pathologically justified therapies remain incomplete. Objective. The aim of the study is to evaluate the effectiveness of the neuroprotector Choline Alphoscerate in eliminating neurological deficits and cognitive impairments in children with TBI. Materials and Methods An analysis of a study was conducted on a group of children aged 1-14 years with brain contusions. The children were divided into two groups: the first group included 35 children with mild brain contusions who received traditional treatment, and the second group included 43 children with moderate brain contusions who, in addition to traditional treatment, received Choline Alphoscerate (CA). Results of the Study.Results of the evaluation using the (CBS) showed that the condition of children with TBI improved in the main group, as scores on the scale decreased. Positive dynamics were also observed in the comparison group; however, the improvement was more pronounced in the group of children who received CA. Scores on the CBS were significantly lower compared to traditional treatment. Stable and progressive improvement in overall condition, neurological status, and intellectual functions was identified in the group of patients whose comprehensive therapy included CA. These findings were further confirmed by the evaluation of children’s intellectual functions using the Raven's test. Conclusions. Choline Alphoscerate effectively eliminates neurological deficits, improves the intellectual performance of children, and prevents disability in cases of TBI.

Keywords: traumatic brain injury, children, treatment.

First page

771

Last page

775

For citation:Artykova M.A., Avezov S.K. - EFFECTIVENESS OF THE NEUROPROTECTOR CHOLINE ALPHOSCERATE IN THE TREATMENT OF CHILDREN WITH TRAUMATIC BRAIN INJURY//New Day in Medicine 12(74)2024 771-775 - https://https://newdayworldmedicine.com/en/new_day_medicine/12-74-2024

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