168 -12 (74) 2024 - Yitmasova T.D. - MORPHOLOGICAL AND EPIDEMIOLOGICAL FEATURES OF DRUG-RESISTANT PULMONARY TUBERCULOSIS IN UZBEKISTAN

MORPHOLOGICAL AND EPIDEMIOLOGICAL FEATURES OF DRUG-RESISTANT PULMONARY TUBERCULOSIS IN UZBEKISTAN

Yitmasova T.D. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

The study examines the morphological and epidemiological features of drug-resistant tuberculosis (DR-TB), with a focus on multidrug-resistant tuberculosis (MDR-TB) in Uzbekistan. The aim is to identify key patterns of disease progression and the challenges in treatment caused by bacterial resistance. Methods included a comprehensive analysis of epidemiological data and morphological observations of lung tissue affected by DR-TB. Results show a high prevalence of primary and secondary resistance in regions with dense populations and active migration, such as Tashkent and the Fergana Valley. Morphological findings revealed extensive lung tissue damage, including giant caverns, caseous necrosis, and lymph node involvement. The research highlights the role of immune suppression in the rapid progression of DR-TB and the necessity for timely and accurate diagnosis. The novelty lies in the regional focus on Uzbekistan and the proposed integration of immunomodulatory therapies with existing chemotherapy protocols to improve patient outcomes. These findings emphasize the importance of adapting global strategies to local epidemiological and healthcare contexts.

Keywords: drug-resistant tuberculosis, multidrug-resistant tuberculosis, Uzbekistan, epidemiology, morphological features, immune suppression, chemotherapy, public health

First page

881

Last page

885

For citation:Yitmasova T.D. - MORPHOLOGICAL AND EPIDEMIOLOGICAL FEATURES OF DRUG-RESISTANT PULMONARY TUBERCULOSIS IN UZBEKISTAN//New Day in Medicine 12(74)2024 881-885 https://https://newdayworldmedicine.com/en/new_day_medicine/12-74-2024

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