172 -12 (74) 2024 - Usmonov I.H., Yitmasova T.D. - TREATMENT EFFICACY AND MORPHOLOGICAL CHANGES IN MULTI-RESISTANT PULMONARY TUBERCULOSIS

TREATMENT EFFICACY AND MORPHOLOGICAL CHANGES IN MULTI-RESISTANT PULMONARY TUBERCULOSIS

Usmonov I.H. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Yitmasova T.D. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

The article examines the morphological changes in the lungs during therapy for multidrug-resistant tuberculosis (MDR-TB). It has been established that this disease is accompanied by significant immunodeficiency, especially in patients with secondary drug resistance. Key morphological features of multidrug-resistant tuberculosis have been identified, including the presence of giant cavities and multiple interconnected cavities replacing a significant portion of the lung tissue. Additionally, bronchial involvement with caseous necrosis and leukocyte infiltration was discovered. The study of lymph nodes revealed specific changes not characteristic of traditional forms of tuberculosis. These data emphasize the necessity for early and accurate diagnosis, as well as the development of new therapeutic strategies to improve the effectiveness of MDR-TB treatment. Special attention is paid to the epidemiological and pathomorphological aspects of the disease, which can improve the prognosis and quality of life for patients.

Keywords: Multidrug-resistant tuberculosis (MDR-TB), drug resistance, immunodeficiency, morphological changes, lung cavities, caseous necrosis, leukocyte infiltration, lymph nodes, pathogenesis, treatment effectiveness.

First page

897

Last page

900

For citation:Usmonov I.H., Yitmasova T.D. - TREATMENT EFFICACY AND MORPHOLOGICAL CHANGES IN MULTI-RESISTANT PULMONARY TUBERCULOSIS //New Day in Medicine 12(74)2024 897-900 https://https://newdayworldmedicine.com/en/new_day_medicine/12-74-2024

List of References

1. Белиловский Е.М., Калиновская А.А. Туберкулез: новые подходы к диагностике и лечению. //Медицинская газета 2020.
2. Гладышев В.А., Иванов С.И. Лекарственная устойчивость микобактерий туберкулеза. //Российский журнал инфекционной патологии, 2019;18(3):45-52.
3. Малышев Н.А., Киселев В.И. Современные проблемы терапии туберкулеза. //Пульмонология, 2018;4:37-45.
4. Сорокина Е.В., Карпова Л.В. Мультирезистентный туберкулез: эпидемиология и лечение. //Российский медицинский журнал, 2017;25(5):123-130.
5. Федотова О.А., Смирнов П.И. Иммунологические аспекты лекарственно-устойчивого туберкулеза. //Вестник фтизиопульмонологии, 2021;29(2):89-96.
6. Петров А.В., Васильев И.А. Морфологические изменения при туберкулезе легких. Патологическая анатомия 2018;22(1):74-81.
7. Никифоров В.В., Сидоров Д.А. Проблемы лечения мультирезистентного туберкулеза. //Медицинский альманах 2019;15(6):55-63.
8. Васильева М.Н., Жукова Т.И. Эффективность новых схем химиотерапии при туберкулезе. //Российский журнал клинической онкологии 2020;14(4):213-220.
9. Ильин Ю.С., Кузнецов А.П. Патогенез и морфология туберкулезного процесса. //Медицинский вестник 2017;21(3):98-104.
10. Савинова О.С., Дмитриев А.Л. Эпидемиологические особенности туберкулеза в России. //Здоровье нации, 2021;33(2):45-51.

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