176 -12 (74) 2024 - Aslonova M.J. - EVALUATION OF THE DETECTABILITY OF THE INTEGRIN ALPHA-2 (PLATELET PLATELET GLYCOPROTEIN IA/IIA ) (ITGA2) GENE POLYMORPHISM IN PREGNANT WOMEN WITH FETAL GROWTH RESTRICTION SYNDROME

EVALUATION OF THE DETECTABILITY OF THE INTEGRIN ALPHA-2 (PLATELET PLATELET GLYCOPROTEIN IA/IIA ) (ITGA2) GENE POLYMORPHISM IN PREGNANT WOMEN WITH FETAL GROWTH RESTRICTION SYNDROME

Aslonova M.J. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

The article presents a molecular genetic study of the polymorphism of the integrin alpha-2 (platelet glycoprotein Ia/IIa) (ITGA2) gene in pregnant women with fetal growth restriction syndrome. Goal: Evaluation of the detectability of the association of the integrin alpha-2 (platelet glycoprotein Ia/IIa) (ITGA2) gene polymorphism in women with the physiological course of pregnancy and fetal growth restriction syndrome in the Uzbek population of the Bukhara region. Materials and methods: 80 pregnant women were examined at the gestation period from 8-36 weeks: 40 pregnant women with fetal growth restriction syndrome and 40 women with physiological pregnancy. The results of the study showed that the functionally unfavorable T allele and the association of polymorphism of the genotype C / T polymorphism of the ITGA2-α2 gene is not a significant determinant of an increased risk of developing SORP in Uzbekistan (χ2<3.8; P>0.05).

Key words: fetal growth restriction syndrome, endothelial system gene, ITGA2 gene

First page

920

Last page

923

For citation:Aslonova M.J. - EVALUATION OF THE DETECTABILITY OF THE INTEGRIN ALPHA-2 (PLATELET PLATELET GLYCOPROTEIN IA/IIA ) (ITGA2) GENE POLYMORPHISM IN PREGNANT WOMEN WITH FETAL GROWTH RESTRICTION SYNDROME//New Day in Medicine 12(74)2024 920-923 https://https://newdayworldmedicine.com/en/new_day_medicine/12-74-2024

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