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  • 181 -12 (74) 2024 - Rahimova L., Mammadbayli A. - MULTIPARAMETRIC ANALYSIS FOR HYPOXIC-ISCHEMIC ENCEPHALOPATHY IN NEWBORNS: IMPACT OF ENVIRONMENTAL, CLINICAL, AND BIOCHEMICAL FACTORS

181 -12 (74) 2024 - Rahimova L., Mammadbayli A. - MULTIPARAMETRIC ANALYSIS FOR HYPOXIC-ISCHEMIC ENCEPHALOPATHY IN NEWBORNS: IMPACT OF ENVIRONMENTAL, CLINICAL, AND BIOCHEMICAL FACTORS

MULTIPARAMETRIC ANALYSIS FOR HYPOXIC-ISCHEMIC ENCEPHALOPATHY IN NEWBORNS: IMPACT OF ENVIRONMENTAL, CLINICAL, AND BIOCHEMICAL FACTORS

Rahimova L. - Azerbaycan Medical University, Samed Vurgun, Baku

Mammadbayli A. - Azerbaycan Medical University, Samed Vurgun, Baku

Garayeva S. - Azerbaycan Medical University, Samed Vurgun, Baku

Resume

Introduction: Hypoxic-ischemic encephalopathy (HIE) is a significant cause of neonatal mortality and both short-term and long-term morbidity. Aim: To evaluate neurological damage in term infants with HIE following perinatal asphyxia and predict outcomes associated with the condition. Materials and Methods: The study included 120 term infants (gestational age ≥37 weeks, birth weight ≥2500 grams) from birth to 1 year of age. The primary cohort consisted of 90 neonates with HIE, classified by severity using a modified Sarnat scale: mild (11.1%), moderate (51.1%), and severe (37.8%). Results: The study results revealed that living in rural areas and lower rates of operative deliveries were associated with an increased risk of HIE. Higher severity of HIE correlated with more pronounced central nervous system (CNS) damage, blood gas composition abnormalities, and electrolyte imbalances. Seizures were most commonly observed in moderate HIE, whereas more severe neurological impairments were recorded in cases of severe HIE. Fractional tissue oxygen extraction (FTOE) decreased with increasing HIE severity and proved to be a reliable predictor of adverse outcomes. A logistic regression model incorporating FTOE and clinical parameters effectively predicted unfavorable outcomes. Conclusion: This study underscores the critical role of environmental, anamnestic, and clinical factors in influencing outcomes in newborns with HIE. Early and comprehensive monitoring is essential for improving prognosis and guiding targeted clinical interventions.

Key words: Hypoxic-ischemic encephalopathy, neonatal mortality.

First page

945

Last page

950

For citation:Rahimova L., Mammadbayli A., Garayeva S. - MULTIPARAMETRIC ANALYSIS FOR HYPOXIC-ISCHEMIC ENCEPHALOPATHY IN NEWBORNS: IMPACT OF ENVIRONMENTAL, CLINICAL, AND BIOCHEMICAL FACTORS//New Day in Medicine 12(74)2024 945-950 https://https://newdayworldmedicine.com/en/new_day_medicine/12-74-2024

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