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  • 49 -1 (75) 2025 - Payzullaeva U.F., Ziyadullaev Sh.Kh. - THE ASSOCIATION OF MICROBIOTA WITH IMMUNOLOGICAL PARAMETERS IN PATIENTS WITH AUTOIMMUNE DISEASES

49 -1 (75) 2025 - Payzullaeva U.F., Ziyadullaev Sh.Kh. - THE ASSOCIATION OF MICROBIOTA WITH IMMUNOLOGICAL PARAMETERS IN PATIENTS WITH AUTOIMMUNE DISEASES

THE ASSOCIATION OF MICROBIOTA WITH IMMUNOLOGICAL PARAMETERS IN PATIENTS WITH AUTOIMMUNE DISEASES

Payzullaeva U.F. - Samarkand State Medical University Uzbekistan

Ziyadullaev Sh.Kh. - Sciences of the Republic of Uzbekistan Uzbekistan

Resume

Gut microbiota is crucial in autoimmune disease (AID) pathogenesis, including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Elevated IL-1β and IL-17 levels were observed, correlating with increased Escherichia coli and Klebsiella pneumoniae and reduced Bifidobacteria and Lactobacillus. In RA, IL-17 and IL-1β reached 113.4 ± 13.3 pg/mL and 43.1 ± 6.2 pg/mL at GSRS≥4. These findings highlight microbiota's role in inflammation and the therapeutic potential of probiotics and prebiotics in improving outcomes.

Keywords: microbiota, cytokines, IL-17, IL-1β, autoimmune diseases.

First page

302

Last page

307

For citation:Payzullaeva U.F., Ziyadullaev Sh.Kh. - THE ASSOCIATION OF MICROBIOTA WITH IMMUNOLOGICAL PARAMETERS IN PATIENTS WITH AUTOIMMUNE DISEASES//New Day in Medicine 1(75)2025 302-307 https://https://newdayworldmedicine.com/en/new_day_medicine/1-75-2025

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