51 -1 (75) 2025 - Asadova N.Kh., Umarkulov B.S. - CHANGES IN THE MORPHOMETRIC INDICATORS OF TESTICULAR PROTEIN MEMBRANE AND COLLAGEN FIBER BUNDLES IN RATS WITH THYROTOXICOSIS IN THE CONTROL AND EXPERIMENTAL GROUPS

CHANGES IN THE MORPHOMETRIC INDICATORS OF TESTICULAR PROTEIN MEMBRANE AND COLLAGEN FIBER BUNDLES IN RATS WITH THYROTOXICOSIS IN THE CONTROL AND EXPERIMENTAL GROUPS

Asadova N.Kh. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Umarkulov B.S. - Republican Specialized Scientific and Practical Medical Center of Endocrinology Jizzakh branch, independent researcher of Bukhara Medical Institute.

Resume

The thyroid gland directly performs its actions on the functioning of the gonads through its hormones. Excess thyroid hormones lead to changes in testicular function. In rats with a thyrotoxicosis model, the testicular epithelium thickened significantly in all areas compared to the control, and it was found that when treated with mercazolil, the epithelium was partially restored, when treated with mercazolil and castor oil, the thickness of the epithelium was slightly improved, and when treated with mercazolil and olive oil, the epithelium was significantly restored, approaching the epithelium of the control group. In rats with a thyrotoxicosis model, collagen fiber bundles in the testicular endothelium were significantly thicker in all areas compared to the control group, while in both conventional and non-conventional treatments, collagen fiber bundles in the endothelium were significantly thinner than in the thyrotoxic group, with greater recovery in the group treated with mercazolyl and olive oil.

Key words: rat, testicles, thyrotoxicosis, protein membrane, collagen fiber bundles.

First page

315

Last page

319

For citation:Asadova N.Kh., Umarkulov B.S. - CHANGES IN THE MORPHOMETRIC INDICATORS OF TESTICULAR PROTEIN MEMBRANE AND COLLAGEN FIBER BUNDLES IN RATS WITH THYROTOXICOSIS IN THE CONTROL AND EXPERIMENTAL GROUPS//New Day in Medicine 1(75)2025 315-319 https://https://newdayworldmedicine.com/en/new_day_medicine/1-75-2025

List of References

1. Xaydarova F.A. ‘‘Yangi O’zbekiston” buqoq qanday kasallik ? 2021 avgust; 3-4 b.
2. Mark P.J. Vanderpump. Oxford academik https://doi.org/10.1093/med/9780199235292.003. 3,1,7-chapter/3074- (2011).
3. Devereaux D., Tewelde S.Z. Hyperthyroidism and thyrotoxicosis. Emerg Med Clin North Am. 2014. 32,277-292.http://dx.doi.org/10.1016/j. emc.2013.12.001
4. Rand Abdulateef Abdullah, Hana Khaleel Ismail and AL-Haaik Ammar Ghanim. Impact of Colchicine on Histology of Testis in RatsWorld Vet J, 2022 September;12(3):250-259. DOI: https://dx.doi.org/10.54203/scil.2022.wvj31
5. Sarkar D., Singh S.K. Effects of neonatal hypothyroidism on prepubertal mouse testis in relation to thyroid hormone receptor alpha 1 (THRalpha1) //Gene Comp Endocrinol. 2017;251:109-120
6. Paulose T.; Speroni L.; Sonnenschein C.; Soto A. Estrogens in the wrong place at the wrong time: fetal BPA exposure and breast cancer. Recycling. //Toxicol. 2014;54:58-65.
7. Radvan M.; Wielgomas B.; Dzievirska E.; Radvan P.; Kaluzny P.; Klimowska A.; Hanke W.; Jurewicz J. Urinary Bisphenol A levels and male fertility. //Am. J. Men's Healing. 2018;12:2144-2151.
8. Kamila Szumilas, Pawel Szumilas, Anna Grzywacz, and Aleksandra Wilk Effects of Electronic Cigarette Vapor Components on the Morphology and Function of the Male and Female Reproductive Systems: //Int. J. Environ. Res. Public Health 2020;1-12(17):6152; https://doi.org/10.3390/ijerph17176152

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