• Home
  • NEW DAY MEDICINE
  • 1 (75) 2025
  • 53 -1 (75) 2025 - L.R. Agababyan, F.B. Hurammova - THE ROLE OF THE MICROBIOME IN THE DEVELOPMENT OF COMPLICATIONS DURING PREGNANCY

53 -1 (75) 2025 - L.R. Agababyan, F.B. Hurammova - THE ROLE OF THE MICROBIOME IN THE DEVELOPMENT OF COMPLICATIONS DURING PREGNANCY

THE ROLE OF THE MICROBIOME IN THE DEVELOPMENT OF COMPLICATIONS DURING PREGNANCY

L.R. Agababyan - Samarkand State Medical University Uzbekistan

F.B. Hurammova - Samarkand State Medical University

Resume

The human microbiota plays a crucial role in maintaining health, including during pregnancy, when changes in the microbiota composition can influence the course of pregnancy and the development of complications. Studies have shown that microbiota imbalance, including vaginal and intestinal microbiota, is associated with conditions such as preeclampsia, gestational diabetes, urinary tract infections, preterm birth, and other obstetric pathologies. The influence of the microbiota on immune, metabolic, and inflammatory regulation can significantly affect the health of the mother and fetus. The use of probiotics, dietary therapy, and antibiotics are the primary methods for correcting microbiota disturbances in pregnant women. Maintaining a healthy microbiota composition through diet and probiotics helps prevent infectious and inflammatory complications, promoting a normal pregnancy.

Keywords: Microbiota, pregnancy, preeclampsia, gestational diabetes, urinary tract infections, probiotics, dietary therapy, dysbiosis, inflammation, immune response.

First page

325

Last page

329

For citation:L.R. Agababyan, F.B. Hurammova - THE ROLE OF THE MICROBIOME IN THE DEVELOPMENT OF COMPLICATIONS DURING PREGNANCY//New Day in Medicine 1(75)2025 325-329 https://https://newdayworldmedicine.com/en/new_day_medicine/1-75-2025

List of References

  1. Бондаренко К.Р., Доброхотова Ю.Э., Новик М.Ю. Возможности профилактики поздних акушерских осложнений путем коррекции эндогенной микробиоты. //Медицинский алфавит. 2017;3(23):6-14.
  2. Доброхотова Ю.Э., Бондаренко К.Р., Шадрова П.А. Роль лактобактерий в восстановлении нормальной микробиоты влагалища. //Вопросы гинекологии, акушерства и перинатологии. 2021;20(2):126-133.
  3. Радзинский В.Е., и др. Пероральные пробиотики: механизм двойного действия в коррекции дисбиозов. Что известно? Акушерство и гинекология: Новости. Мнения. Обучения. 2023;11(5):85-90.
  4. Собель Дж.Д., и др. Микробные причины вагинита. //Клинические микробиологические обзоры. 2017;30(3):577-603.
  5. Кира Е.Ф. Пробиотики в восстановлении микробиоценоза влагалища. Акушерство и гинекология. 2017;5:32-38.
  6. Davidson S, Barrett H, Price S, Callaway L, Dekker Nitert M. Probiotics for preventing gestational diabetes. Cochrane Database Syst Rev 2021;4:CD009951, https://doi.org/10.1002/14651858.CD009951.pub3.
  7. DiGiulio DB, Callahan BJ, McMurdie PJ, Costello EK, Lyell DJ, Robaczewska A, Sun CL, Goltsman DSA, Wong RJ, Shaw G, et al. Temporal and spatial variation of the human microbiota during pregnancy. //Proc Natl Acad Sci 2015;112:11060-11065.
  8. Domingues RM, Rodrigues JF, Santos J, et al. Microbiota dynamics and its impact on vaginal health during pregnancy: a comprehensive review. //Curr Opin Microbiol. 2021;74:1-8.
  9. Isolauri E, Salminen S, von Wright M, et al. Probiotics and Prebiotics: Basic Principles and Applications. Wiley-Blackwell; 2015.
  10. Jang Y, Kim M, Hong S, et al. Probiotics and their effect on preventing and treating infections during pregnancy: A systematic review. //J Korean Med Sci. 2020;35(1):e72.
  11. Jarde A, Lewis-Mikhael A-M, Moayyedi P, Stearns JC, Collins SM, Beyene J, McDonald SD. Pregnancy outcomes in women taking probiotics or prebiotics: a systematic review and meta-analysis. //BMC Pregnancy Childbirth. 2018;18(1):14.
  12. Koren O, Goodrich JK, Cullender TC, et al. Host remodeling of the gut microbiome and metabolic changes during pregnancy. //Cell. 2012;150(3):715-725.
  13. Mendling W, Ziklo N, Smith C, et al. Vaginal microbiota and the risk of preterm birth. //Eur J Obstet Gynecol Reprod Biol. 2020;246:65-69.
  14. Nuriel-Ohayon M, Neuman H, Koren O. Microbial changes during pregnancy, birth, and infancy. //Front Microbiol. 2016;7:1031.
  15. Vrieze A, Van Nood E, Holleman F, et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. //Gastroenterology 2018;145(3):573-583.
  16. Zhang C, Yang L, Yao J, et al. Gut microbiome changes in pregnancy and the development of gestational diabetes. //Front Microbiol. 2020;11:568.
  17. Zmora N, Zilberman-Schapira G, Suez J, et al. Personalized gut mucosal colonization resistance to empiric probiotics is associated with unique host and microbiome features. //Cell. 2018;174(7):1388-1405.

    file

    download