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83 -1 (75) 2025 - G.A.Ixtiyarova, D.Sh.Kudratova - CURRENT METHODS OF PREIMPLANTATION GENETIC DIAGNOSIS IN THE REPUBLIC OF UZBEKISTAN

CURRENT METHODS OF PREIMPLANTATION GENETIC DIAGNOSIS IN THE REPUBLIC OF UZBEKISTAN

G.A.Ixtiyarova - Bukhara State Medical Institute named after Abu Ali ibn Sina

D.Sh.Kudratova - Tashkent State Dental Institute Uzbekistan

Resume

Preimplantation genetic diagnosis has existed for more than 20 years, during which time the range of possibilities of assisted reproductive technologies and the potential of molecular genetic diagnosis of single cells have significantly expanded. To date, preimplantation diagnosis has evolved from an experimental procedure to a valid and earliest form of prenatal diagnosis, while expanding the range of indications.   Women of older reproductive age - 35 years and older. Couples with a history of more than three spontaneous early terminations of pregnancy (habitual miscarriage). Men with severe disorders of spermatogenesis - oligoasthenoteratozoospermia, severe oligozoospermia, azoospermia. Couples with repeated unsuccessful IVF attempts - more than three unsuccessful attempts.  Mitochondrial diseases caused by nuclear DNA mutations are transmitted according to Mendelian laws, hence the pattern of PGD should be the same as for monogenic diseases. The inheritance of mitochondrial diseases caused by mtDNA mutations is complicated by heteroplasmy (genetic heterogeneity of the mitochondrial population), different levels of heteroplasmy in different oocytes, random distribution of mtDNA molecules between blastocyst cells, and the fact that the proportion of mutant mtDNA molecules may vary differently in tissues during the development and life of the organism. This has transformed PGD from an experimental procedure to a valid and earliest form of PD, while expanding the range of indications.

Keywords: preimplantation genetic diagnosis; prenatal diagnosis

First page

482

Last page

488

For citation:G.A.Ixtiyarova, D.Sh.Kudratova - CURRENT METHODS OF PREIMPLANTATION GENETIC DIAGNOSIS IN THE REPUBLIC OF UZBEKISTAN//New Day in Medicine 1(75)2025 482-488 https://https://newdayworldmedicine.com/en/new_day_medicine/1-75-2025

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