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87 -1 (75) 2025 - Safoeva S.M. - PRINCIPLES OF FORMING A PATHOGENETICALLY SUBSTANTIATED DIAGNOSIS FOR HYPERANDROGENISM IN WOMEN OF REPRODUCTIVE AGE

PRINCIPLES OF FORMING A PATHOGENETICALLY SUBSTANTIATED DIAGNOSIS FOR HYPERANDROGENISM IN WOMEN OF REPRODUCTIVE AGE

Safoeva S.M. - Perinatal Medicine of Center for the Development of Professional Qualifications of Medical Workers Tashkent

Resume

Hyperandrogenism syndrome is considered one of the leading causes of menstrual irregularities, endocrine infertility and miscarriage [1,2]. The cause of hyperandrogenism in women of childbearing age may be polycystic ovary syndrome, a nonclassical form of congenital adrenal cortex dysfunction, androgen-secreting tumors, severe insulin resistance syndrome, idiopathic hyperprolactinemia and thyroid pathology, in particular hypothyroidism. Polycystic ovary syndrome (PCOS) and thyroid hypofunction are the most common endocrine disorders among women of reproductive age. According to studies of thyroid disease, mainly hypothyroidism, autoimmune thyroiditis (AIT) and PCOS are closely related. Hypothyroidism and AIT can cause PCOS, worsen a woman's condition and worsen the metabolic, reproductive, and psychological complications of PCOS. This article shows the results of a diagnostic search for the genesis of hyperandrogenism in 220 women with impaired menstrual and/or reproductive function and symptoms of hyperandrogenism.

Keywords: polycystosis of ovaries, hyperandrondrogenia, hypofunction of thyroid gland

First page

506

Last page

512

For citation:Safoeva S.M. - PRINCIPLES OF FORMING A PATHOGENETICALLY SUBSTANTIATED DIAGNOSIS FOR HYPERANDROGENISM IN WOMEN OF REPRODUCTIVE AGE//New Day in Medicine 1(75)2025 506-512 https://https://newdayworldmedicine.com/en/new_day_medicine/1-75-2025

List of References

  1. Заславский ДВ. Дерматологические аспекты значения гиперандрогенизма при синдроме поликистозных яичников. Прокопенко АД, Даниелян Д.А. //Современные проблемы науки и образования. 2018;4:144-144.
  2. Сагл М. Рецидивирующий ранний выкидыш и поликистоз яичников. Сагл М, Бишоп К., Ридли Н., Александр Ф.М., Мишель М., Бонни Р.С., Борода Р.В., Фрэнкс С. //British Medical Journal 1988; doi: https://doi.org/10.1136/bmj.297.6655.1027.
  3. Nestler, J. E., Stovall, D., Akhter, N., Iuorno, M. J., Jakubowicz, D. J. (2002). Strategies for the use of insulin-sensitizing drugs to treat infertility in women with polycystic ovary syndrome. //Fertility and Sterility 2002;77(2) https://doi.org/10.1016/S0015-0282(01)02963-6
  4. Martin, Kathryn A et al. “Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline.” //The Journal of clinical endocrinology and metabolism 2018;103(4) doi:10.1210/jc.2018-00241
  5. Witchel, Selma Feldman et al. “Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls.” //Journal of the Endocrine Society 2019;3(8) doi:10.1210/js.2019-00078
  6. Escobar-Morreale H.F. et al. “Epidemiology, diagnosis and management of hirsutism: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome Society.” //Human reproduction update 2012;18(2) doi:10.1093/humupd/dmr042
  7. Azziz Ricardo et al. “The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report.” //Fertility and sterility 2009;91(2) doi:10.1016/j.fertnstert.2008.06.035
  8. Teede Helena J et al. “Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome.” //Human reproduction (Oxford, England) 2018;33(9) doi:10.1093/humrep/dey256
  9. Teede Helena J et al. “Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome.” //The Journal of clinical endocrinology and metabolism 2023;108(10) doi:10.1210/clinem/dgad463
  10. Асатова М.М., Хегай О.А. Синдром яичниковой недостаточности: принципы диагностики и лечения. Руководство для врачей 2019.
  11. Khadilkar Suvarna Satish. “Polycystic Ovarian Syndrome: Is It Time to Rename PCOS to HA-PODS?.” //Journal of obstetrics and gynaecology of India 2016;66(2) doi:10.1007/s13224-016-0851-9
  12. Древаль А.В., Комердус И.В., Мурзина А.В., Нечаева О.А., Тишенина Р.С., Бородина Е.Г., Анашкина Г.А. Распространенность субклинического гиперкортицизма среди больных с сахарным диабетом 2-го типа и алиментарным ожирением. //Проблемы эндокринологии. 2014;60(1) DOI: 10.18786/2072-0505-2016-44-4-430-438
  13. Ding, Xiaohong et al. “Subclinical Hypothyroidism in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis.” //Frontiers in endocrinology 2018; 9. doi:10.3389/fendo.2018.00700