70 -2 (76) 2025 - Mukhitdinova K.О., Aleinik V.A. - EFFECT OF GENITAL INFECTIONS ON THE ALTERATION OF LEUKOCYTE DNA METHYLATION IN WOMEN WITH EARLY PREGNANCY

EFFECT OF GENITAL INFECTIONS ON THE ALTERATION OF LEUKOCYTE DNA METHYLATION IN WOMEN WITH EARLY PREGNANCY

Mukhitdinova K.О. - Andijan State Medical Institute

Aleinik V.A. - Andijan State Medical Institute

Babich S.M. - Andijan State Medical Institute

Negmatshaeva Kh.N. - Andijan State Medical Institute

Zhuraev B.M. - Andijan State Medical Institute

Resume

The study analyzed how genital infections affect leukocyte DNA methylation in women facing early pregnancy failure. The findings show that women who were able to complete pregnancy and labor but had genital infections before conception had a harmonious ratio of pro-inflammatory (TNF-α, IL-1β) and anti-inflammatory (IL-10) cytokines, as well as balanced levels of matrix metalloproteinases and moderate epigenetic changes. These factors contribute to adequate immune regulation, which in turn supports a successful pregnancy even in the presence of infection. In contrast, women who experienced miscarriages before 12 weeks' gestation and had genital infections prior to pregnancy show different immune responses and less resistance to complications, emphasizing the importance of immune response balance in the context of reproductive health. A pronounced cytokine imbalance (high FNO-α, IL-1β; low IL-10) is indicative of excessive inflammation and the risk of complications associated with miscarriages. Significant increase in MMP and decrease in TIMP can compromise tissue integrity, worsening the conditions for pregnancy. Increased DNA methylation (elevated DNMT1 and 5-methyl-2'-deoxycytidine) indicates epigenetic disorders potentially affecting immune adaptation and reproductive function.

Keywords: interleukins, proteases, protease inhibitors, DNA methyltransferase 1, early pregnancy, pregnancy failure, DNA methylation, genital infections.

First page

377

Last page

384

For citation:Mukhitdinova K.О., Aleinik V.A., Babich S.M., Negmatshaeva Kh.N., Zhuraev B.M. - EFFECT OF GENITAL INFECTIONS ON THE ALTERATION OF LEUKOCYTE DNA METHYLATION IN WOMEN WITH EARLY PREGNANCY//New Day in Medicine 2(76)2025 377-384 https://https://newdayworldmedicine.com/en/new_day_medicine/2-76-2025

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