25 -6 (38) 2021 — M.A. Sabirov, N.N. Sultonov, — A MODERN APPROACH TO ANTI-AGGREGATE TREATMENT FOR CHRONIC KIDNEY DISEASE

A MODERN APPROACH TO ANTI-AGGREGATE TREATMENT FOR CHRONIC KIDNEY DISEASE

M.A. Sabirov, Republican Specialized Scientific and Practical Medical Center for Nephrology and Kidney Transplantation, Uzbekistan

N.N. Sultonov, Republican Specialized Scientific and Practical Medical Center for Nephrology and Kidney Transplantation, Uzbekistan

S.N. Isirgapova, Republican Specialized Scientific and Practical Medical Center for Nephrology and Kidney Transplantation, Uzbekistan

M.Kh. Tashpulatova Republican Specialized Scientific and Practical Medical Center for Nephrology and Kidney Transplantation, Uzbekistan

Resume

In the study evaluated the effectiveness of antiplatelet therapy in patients with chronic kidney disease. In the treatment of patients with the disease were divided into two groups: the first group received thrombosepin 200 mg / day in the quality of antiplatelet therapy, and the second group received dipyridamole. 225 mg / day.The study was monitored for 90 days, changes in the hemostatic system in patients were monitored. In patients with stage II-III SBK on the background of antiaggregant therapy in group 1 decreased platelet aggregation by 16.2% (R <0.01), fibrinogen by 22.2%, thrombus test by 29.6% (R <0.001), AChTV by 28.75%. (R <0.001). In our group 2 patients, platelet aggregation decreased by 19.2% (R <0.01), fibrinogen by 25.9%, thrombus test by 30.18% (R <0.001), and AChTV by 24.48% (R <0.001). . Hence, changes in platelet aggregation and hemostasis system when using Alltrombosepin as an antiaggregant drug were observed to be no different from dipyridamole drug used in standard treatment.

Key words: chronic kidney disease, hemostatic system, antiplatelet agent, alltombosepin, dipyridamole.

First page

135

Last page

144

For citation: M.A. Sabirov, N.N. Sultonov, S.N. Isirgapova, M.Kh. Tashpulatova A MODERN APPROACH TO ANTI-AGGREGATE TREATMENT FOR CHRONIC KIDNEY DISEASE //New Day in Medicine 6(38)2021 135-144 https://cutt.ly/cYur0aA

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