10 -3 (77) 2025 - Kobilov E.E., Barotova M.R. - CORRECTION OF LIVER DYSFUNCTION IN CHILDREN WITH CHRONIC GASTRITIS

CORRECTION OF LIVER DYSFUNCTION IN CHILDREN WITH CHRONIC GASTRITIS

Kobilov E.E. - Samarkand State University named after Sharaf Rashidov

Barotova M.R. - Samarkand State Medical University

Tuxtayev M.K. - Samarkand State University named after Sharaf Rashidov

Resume

Aim. Clinical and laboratory evaluation of the effectiveness of Essentiale-forte and medical glycerin in the correction of liver dysfunction in children with chronic gastritis (СhG). Materials and methods: The article presents data from 34 patients with chronic gastritis (ChG). All patients were divided into four groups: I-group consisted of 10 patients with ChG who received conventional treatment methods; II-group consisted of 9 patients with ChG who received essentiale along with conventional treatment (2 capsules 2 times a day after meals); III-group consisted of 7 patients with ChG who received in the complex of medicinal products, medical glycerin (at a dose of 0.5 mg / kg of weight dissolved in 200.0 ml of boiled water, every 2 days); The IV group included 8 patients with ChG who received complex treatment, including conventional methods of treatment, essentiale and glycerin, for the entire period of treatment. Results. In patients with ChG, a change in the functional state of the liver, an increase in nitrogen metabolism, a statistically significant increase in the concentration of ammonia and urea in the blood of patients with ChG, compared with healthy children, was revealed. The concentration of nitrogenous compounds (ammonia, urea) in the blood of patients with ChG underwent significant changes after glycerin loading, in particular, a decrease in the content of ammonia in the blood by 59.1 mmol/l, urea by 0.57 mmol/l and glutamine by 11.65 mmol/l was noted. We have identified some interrelated changes between the pathological process in ChG and the functional state of the liver, in particular the high content of nitrogenous compounds caused by metabolic disorders in the body of ChG patients. Conclusion. The data obtained indicate that, along with traditional treatment, the combined use of Essentiale -forte and medical glycerin additionally makes it possible to correct changes in clinical and biochemical parameters in patients with ChG in a shorter time. Comprehensive treatment of children with essential hypertension and medical glycerin is pathogenetically justified, has a positive effect on the course of the disease and helps to reduce the duration of inpatient treatment.

Key words: children, chronic gastritis, nitrogen metabolism, functional state of the liver, ammonia, glutamine, urea, correction, Essentiale, medical glycerin.

First page

46

Last page

52

For citation:Kobilov E.E., Barotova M.R., Tuxtayev M.K. - CORRECTION OF LIVER DYSFUNCTION IN CHILDREN WITH CHRONIC GASTRITIS//New Day in Medicine 3(77)2025 46-52 https://https://newdayworldmedicine.com/en/new_day_medicine/3-77-2025

List of References

  1. Ivashkin V.T., Mayev I.V. (2021). Clinical recommendations of the Russian Gastroenterological Association and the Association "Endoscopic Society of RANDO" on the diagnosis and treatment of gastritis, duodenitis // Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2021;31(4):70-99.
  2. Korotkevich A.G. (2018). On the endoscopic classification of chronic gastritis / A.G. Korotkevich, P.V. Aksenov // Experimental and clinical gastroenterology. 2018;152(4):53-60.
  3. Kushnir E. (2022). "Pain in the right side is most likely not the liver": 11 questions to hepatologist Maria Prashnova / E. Kushnir, M. Prashnova // Tinkoff-journal. 2022 June 22.
  4. Nurmatova N. F., Inoyatova F. I. (2021). The functional state of the liver in children with chronic hepatitis b and intestinal giardiasis. // Children's Medicine of the North-West 2021;9(1):262-263.
  5. Zaccherini G., Weiss E., Moreau R. (2020). Acute-on-chronic liver failure: Definitions, pathophysiology and principles of treatment. // JHEP Rep; 2020;3(1):100-176.
  6. Li F., Thuluvath P.J. (2021). EASL-CLIF criteria outperform NACSELD criteria for diagnosis and prognostication in ACLF. // J Hepatol 2021;75(5):1096-1103.
  7. Kobilov E. E., Batirov Kh. F., Ozdamirova E. M. Urban Ecosystems of Uzbekistan and Ways of Their Ecologization. // BIO Web of Conferences 63, 03002 (2023) ASE-2023 https://doi.org/10.1051/bioconf/20236303002
  8. E. E. Kobilov, Kh. F. Batirov, S. A. Aslakhanova. Food Supply as the Main Factor of People’s Quality of Life. SHS Web of Conferences 172, 02007 (2023) SHCMS 2023. https://doi.org/10.1051/shsconf/202317202007
  9. Uralov Shukhrat, E.E.Kobilov, H.F.Batirov, M.K.Tukhtaev, V.B. Agzamov. Clinical and anamnestic characteristics of children with chronic gastroduodenal pathology. BIO Web of Conferences Volume 76 (2023) I International Conference “Biotechnologies in the Context of Human Development” (BCHD - 2023). Osh, Kyrgyzstan, Grozny, Russia, July 21, 2023 BIO Web of Conferences 76, 01014 (2023) BCHD – 2023. https://doi.org/10.1051/bioconf/20237601014 https://www.bio-conferences.org/articles/bioconf/abs/2023/21/contents/contents.html
  10. Alberto Pietro Damiano Baltrocchi, Lucrezia Maggi, Bruno Dal Lago, Vincenzo Torretta, Márta Szabó, Muhtor Nasirov, Ergash Kabilov, Elena Cristina Rada. Mechanisms of Diffusion of Radon in Buildings and Mitigation Techniques. Sustainability jurnali, Sustainability 2024;16:324. https://doi.org/10.3390/su16010324 https://www.mdpi.com/journal/sustainability

    file

    download