25 -3 (77) 2025 - Abdullaev Kh.D. - DETERMINING THE EFFECTIVENESS OF METHOTREXATE IN THE TREATMENT OF PSORIASIS

DETERMINING THE EFFECTIVENESS OF METHOTREXATE IN THE TREATMENT OF PSORIASIS

Abdullaev Kh.D. - Samarkand State Medical University

Resume

The objective of our study was to determine the effectiveness of the use of methotrexate in the treatment of psoriasis. To fulfill our tasks, we examined 36 patients aged 15 to 35 years, the patients were divided into 2 groups, the control and the main one. In the control group there were 18 patients with psoriasis, 7 women and 11 men. Psoriatic plaques in patients were sevenfold on the knee joints, elbow joints, as well as the presence of papules with scales in the scalp. This group was treated with the systemic drug Methotrexate (Methotrexate 50 mg 5 ml). The dose of the drug was selected for each patient depending on the weight of the patients (0.25 per 1 kg of body weight). Also, to prevent side effects of the drug, patients were prescribed folic acid 1 tablet 3 times throughout the study. The main group included 6 women and 12 men. Psoriatic plaques in patients were sevenfold on the knee joints, elbow joints, as well as the presence of papules with scales in the scalp. This group was treated with the systemic drug Methotrexate (Methotrexate 50 mg 5 ml). For each patient, the dose of the drug was selected depending on the age of the patients (from 15-20 years old, the dose of the drug was 20 mg 5 ml, 21-25 years old, the dose of the drug was 25 mg 5 ml, 26-30 years old, the dose of the drug was 30 mg 5 ml). As a result of our research, we came to the conclusion that it is more effective to treat patients with psoriasis with the drug methotrexate 50 kg 5 ml according to the 0.25 mg per kg body weight scheme and maintain the regression period for a longer time, in contrast to the main group. This treatment regimen is recommended for the treatment of moderate to severe psoriasis.

Key words: Psoriasis, methotrexate, treatment.

First page

130

Last page

134

For citation:Abdullaev Kh.D. - DETERMINING THE EFFECTIVENESS OF METHOTREXATE IN THE TREATMENT OF PSORIASIS//New Day in Medicine 3(77)2025 130-134 https://https://newdayworldmedicine.com/en/new_day_medicine/3-77-2025

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