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  • 30 -3 (77) 2025 - Sadikov S.S., Abdullaev R.B. - ANALYSIS OF BIOCHEMICAL AND HEMATOLOGICAL INDICATORS IN CHRONIC LIVER DISEASES

30 -3 (77) 2025 - Sadikov S.S., Abdullaev R.B. - ANALYSIS OF BIOCHEMICAL AND HEMATOLOGICAL INDICATORS IN CHRONIC LIVER DISEASES

ANALYSIS OF BIOCHEMICAL AND HEMATOLOGICAL INDICATORS IN CHRONIC LIVER DISEASES

Sadikov S.S. - Urgench branch of the Tashkent Medical Academy Uzbekistan

Abdullaev R.B. - Urgench branch of the Tashkent Medical Academy Uzbekistan

Matkarimova D.S. - Tashkent Medical Academy

Resume

Target. To analyze the state of biochemical and hematological parameters in chronic liver diseases. Material and methods. The material for the study included 156 patients with CKD (1st main group) and 80 healthy patients without liver disease (4th comparison control group). The median age of those examined was 53.3±1.4 years. Among all the studied individuals, biochemical and hematological blood tests were carried out to determine the content of ferritin, vitamin B12 and folic acid in the blood serum (biochemical and hematological automatic analyzers “Mindray, China”). Statistical calculations of the obtained results were carried out using the statistical software package “OpenEpi 2009, Version 9.2”. Conclusions: signs of worsening liver damage, in particular with cirrhosis, in biochemical and general blood tests are more pronounced changes in the presented indicators, which are very important laboratory signs that make it possible to prevent the worsening of the disease in the early stages of the development of cirrhosis through their timely correction.

Key words: chronic liver diseases, chronic hepatitis, liver cirrhosis, biochemical changes, hemogram, severity.

First page

159

Last page

162

For citation:Sadikov S.S., Abdullaev R.B., Matkarimova D.S. - ANALYSIS OF BIOCHEMICAL AND HEMATOLOGICAL INDICATORS IN CHRONIC LIVER DISEASES//New Day in Medicine 3(77)2025 159-162 https://https://newdayworldmedicine.com/en/new_day_medicine/3-77-2025

List of References

  1. Sadikov S.S., Abdullaev R.B., Matkarimova D.S. The contribution of molecular genetic factors to the mechanisms of formation of chronic liver diseases // “O’zbekiston Harbiy Tibbiyoti” ilmiy-amaliy journal, 2024;4:61-64.
  2. Sadikov S.B., Abdullaev R.B., Matkarimova D.S., Boboev K.T. Analysis of the role of polymorphism C-174G of the interleukin IL6 gene in chronic liver diseases // Biology va tibbiyot muammolari. 2024;4/5:(155)211-214.
  3. Asrani S. K. et al. Burden of liver diseases in the world // Journal of hepatology. 2019;70(1):151-171.
  4. Cheemerla S., Balakrishnan M. Global epidemiology of chronic liver disease // Clinical liver disease. 2021;17(5):365-370.
  5. Marcellin P, Kutala BK. Liver diseases: A major, neglected global public health problem requiring urgent actions and large-scale screening. // Liver Int 2018;38:2-6.
  6. Ramachandran P, Matchett KP, Dobie R, Wilson-Kanamori JR, Henderson NC. Single-cell technologies in hepatology: new insights into liver biology and disease pathogenesis. // Nat Rev Gastroenterol Hepatol 2020;17:457-72.
  7. Sepanlou SG, Safiri S, Bisignano C, Ikuta KS, Merat S, Saberifiroozi M, et al. The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017: a systematic analysis for the global burden of disease study 2017. // Lancet Gastroenterol 2020;5:245-66.
  8. Ismailov U. S., Batirov D. Y., Boboev K. T., Rakhimov A. P. (2021). Molecular-genetic basis in the pathogenesis of nosological synthropy of gallstone disease and metabolic syndrome. // Central Asian Journal of Medicine, 2021;(4):133-140.
  9. Ismailov U.S., Batirov D.Y., Rakhimov A.P., Tillaev M.T., Akhmedov Sh.S., Some molecular genetic aspects of the development of gallstone disease with metabolic syndrome in the uzbek population // New Day in Medicine 2022;9(47):144-150 https://l.clck.bar/5b4e1
  10. Wong M. C. S. et al. The changing epidemiology of liver diseases in the Asia–Pacific region // Nature reviews Gastroenterology hepatology. 2019;16(1):57-73.
  11. Xiao J. et al. Global liver disease burdens and research trends: analysis from a Chinese perspective // Journal of hepatology. 2019;71(1):212-221.
  12. Younossi Z. M. et al. Epidemiology of chronic liver diseases in the USA in the past three decades // Gut. 2020;69(3):564-568.

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