30 -6 (36) 2021 — Nasirjan Mukhamedjanovich Yuldashev — MOLECULAR BIOLOGY OF MEMBRANE-BINDED PROTEINS OF CORONAVIRUSES

MOLECULAR BIOLOGY OF MEMBRANE-BINDED PROTEINS OF CORONAVIRUSES

Nasirjan Mukhamedjanovich Yuldashev Tashkent Pediatric Medical Institute, Republic of Uzbekistan, Tashkent;

Resume

In this paper, we analyze the scientific literature on membrane-bound proteins of coronaviruses. Only three main proteins of the coronavirus membrane — protein M, E, and S — were examined in the paper. Modification of these proteins by glycosylation and palmitoylation was examined. The role of modifications in the assembly of virions and virulence is discussed. The conclusion is drawn on the importance of studying the membrane proteins of coronaviruses to develop an effective vaccine against them.

Key words: coronaviruses, M protein, E protein, S protein, glycosylation, palmitoylation.

First page

164

Last page

174

For citation: Nasirjan Mukhamedjanovich Yuldashev MOLECULAR BIOLOGY OF MEMBRANE-BINDED PROTEINS OF CORONAVIRUSES//New Day in Medicine 6(38)2021 164-174 https://cutt.ly/6YgYMFf

LIST OF REFERENCES:

  1. Biologicheskiy entsiklopedicheskiy slovar’ / Gl. red. M.S. Gilyarov; Redkol.: A.A. Bayev, G.G. Vinberg, G.A. Zavarzin i dr. – M.: Sov. Entsiklopediya, 1986. – 831 s.
  2. King A.M.Q., Lefkowitz E., Adams M.J., Carstens E.B. Virus Taxonomy: Ninth Report of the International Committee on Taxonomy of Viruses. – Elsevier, 2011. – P. 6. – ISBN 0-12-384684-6.136
  3. David L. Heymann, Nahoko Shindo. COVID-19: what is next for public health? // The Lancet. – Elsevier, 2020. – 13 February. – ISSN 1474-547X 0140-6736, 1474-547X. – doi:10.1016/S0140-6736(20)30374-3.
  4. Profilaktika, diagnostika i lecheniye novoy koronavirusnoy infektsii (COVID-19). Vremennyye metodicheskiye rekomendatsii. Ministerstvo zdravookhraneniya Rossiyskoy Federatsii. (3 marta 2020).https://www.who.int/publications-detail/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected
  5. Atlas po meditsinskoy mikrobiologii, virusologii i immunologii: Uchebnoye posobiye dlya studentov meditsinskikh vuzov / pod red. A.A. Vorob’yova, A.S. Bykova. – M.: Meditsinskoye informatsionnoye agentstvo, 2003. – S. 121. –ISBN 5-89481-136-8.
  6. Content Providers(s): CDC/Dr. Fred Murphy – This media comes from the Centers for Disease Control and Prevention’s Public Health Image Library (PHIL), with identification number #4814, https://commons.wikimedia.org/w/index.php? сurid=822112.
  7. Goldsmith C.S., Tatti K.M., Ksiazek T.G., et al. Ultrastructural characterization of SARS coronavirus. Emerg Infect Dis. 2004; 10(2):320–326. doi:10.3201/eid1002.030913
  8. Masters P.S. The molecular biology of coronaviruses. Adv. Virus Res. 66, 193–292 (2006);
  9. Entedar A.J. Alsaadi, Ian M.J. Membrane binding proteins of coronaviruses // Future virology. – vol. 14, № 4. https://doi.org/10.2217/fvl-2018-0144
  10. Wang J., Fang S., Xiao H., Chen B., Tam J.P., Liu D.X. Interaction of the coronavirus infectious bronchitis virus membrane protein with β-actin and its implication in virion assembly and budding. PLoS ONE 4(3), e4908 (2009).
  11. To Sing Fung & Ding Xiang Liu Post-translational modifications of coronavirus proteins: roles and function FUTURE VIROLOGY VOLUME 13, ISSUE 6 / JUNE 2018 405–430
  12. de Haan C.A., Roestenberg P., de Wit M. et al. Structural requirements for O-glycosylation of the mouse hepatitis virus membrane protein. J. Biol. Chem. 273(45), 29905–29914 (1998).
  13. Oostra M., de Haan C.A., de Groot R.J., Rottier P.J. Glycosylation of the severe acute respiratory syndrome coronavirus triple-spanning membrane proteins 3a and M. J. Virol. 80(5), 2326–2336 (2006).
  14. Kuo L., Hurst-Hess K.R., Koetzner C.A., Masters P.S. Analyses of coronavirus assembly interactions with interspecies membrane and nucleocapsid protein chimeras. J. Virol. 90(9), 4357–4368 (2016).
  15. Holmes K.V., Doller E.W., Sturman L.S. Tunicamycin resistant glycosylation of coronavirus glycoprotein: demonstration of a novel type of viral glycoprotein. Virology 115(2), 334–344 (1981).
  16. Stern D.F., Sefton B.M. Coronavirus proteins: structure and function of the oligosaccharides of the avian infectious bronchitis virus glycoproteins. J. Virol. 44(3), 804–812 (1982).
  17. Hu Y., Wen J., Tang L. et al. The M protein of SARS-CoV: basic structural and immunological properties. Genomics Proteomics Bioinformatics 1(2), 118–130 (2003).
  18. Voss D., Kern A., Traggiai E. et al. Characterization of severe acute respiratory syndrome coronavirus membrane protein. FEBS Lett. 580(3), 968–973 (2006).
  19. Braakman I., van Anken E. Folding of viral envelope glycoproteins in the endoplasmic reticulum. Traffic 1(7), 533–539 (2000).
  20. de Haan C.A., de Wit M., Kuo L. et al. The glycosylation status of the murine hepatitis coronavirus M protein affects the interferogenic capacity of the virus in vitro and its ability to replicate in the liver but not the brain. Virology 312(2), 395–406 (2003).

file

download