• Home
  • NEW DAY MEDICINE
  • 3 (77) 2025
  • 52 -3 (77) 2025 - Usmanova Z.A., Rozikhodjaeva G.A. - ACTIVITY OF MATRIX METALLOPROTEINASE-9 AND ITS TISSUE INHIBITOR-1 IN SERUM, AS WELL AS ZINC LEVELS IN VARIOUS BIOLOGICAL SAMPLES IN PATIENTS WITH CAROTID ATHEROSCLEROSIS AFTER STROKEь

52 -3 (77) 2025 - Usmanova Z.A., Rozikhodjaeva G.A. - ACTIVITY OF MATRIX METALLOPROTEINASE-9 AND ITS TISSUE INHIBITOR-1 IN SERUM, AS WELL AS ZINC LEVELS IN VARIOUS BIOLOGICAL SAMPLES IN PATIENTS WITH CAROTID ATHEROSCLEROSIS AFTER STROKEь

ACTIVITY OF MATRIX METALLOPROTEINASE-9 AND ITS TISSUE INHIBITOR-1 IN SERUM, AS WELL AS ZINC LEVELS IN VARIOUS BIOLOGICAL SAMPLES IN PATIENTS WITH CAROTID ATHEROSCLEROSIS AFTER STROKE

Usmanova Z.A. - Center for the Development of Professional Qualifications of Medical Workers under the Ministry of Health of the Republic of Uzbekistan

Rozikhodjaeva G.A. - Clinical Hospital №1 of the Head Medical Department under the Administration of the of the President of the Republic of Uzbekistan

Resume

The levels of zinc in blood serum, hair, and atherosclerotic plaques of the carotid artery, as well as the concentrations of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in serum, were studied in patients with carotid atherosclerosis without symptoms and in those who had suffered a stroke. In patients with carotid atherosclerosis who had suffered a stroke, the TIMP-1 level in serum was higher than in patients without symptoms. In patients with symptomatic carotid atherosclerosis, the zinc level in serum and atherosclerotic plaques was lower than in patients without symptoms. This confirms the significant role of zinc levels in biological samples in the pathogenesis of carotid atherosclerosis complications. An increase in blood glucose concentration is accompanied by a decrease in zinc levels in hair. As the MMP-9 level in blood rises, the zinc concentration in serum increases, while in hair, it decreases.

Key words: matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, zinc of the serum, hair, atherosclerotic plaques of carotid artery, carotid atherosclerosis, stroke.

First page

280

Last page

285

For citation:Usmanova Z.A., Rozikhodjaeva G.A. - ACTIVITY OF MATRIX METALLOPROTEINASE-9 AND ITS TISSUE INHIBITOR-1 IN SERUM, AS WELL AS ZINC LEVELS IN VARIOUS BIOLOGICAL SAMPLES IN PATIENTS WITH CAROTID ATHEROSCLEROSIS AFTER STROKE//New Day in Medicine 3(77)2025 280-285 https://https://newdayworldmedicine.com/en/new_day_medicine/3-77-2025

List of References

  1. Гаврилова Н.Е., Метельская В.А., Перова Н.В. и др. Взаимосвязь между выраженностью коронарного атеросклероза, факторами риска и маркерами атеросклеротического поражения каротидных и периферических артерий // Кардиоваскулярная терапия и профилактика. 2013;12(1):40-45.
  2. Шишкина В.С., Токлуева Л.Р., Каширина С.В. и др. Сопоставление морфологических особенностей атеросклеротических бляшек сонных артерий и клинико-инструментальных данных у пациентов с выраженным каротидным атеросклерозом // Кардиология. 2013;4:25-31.
  3. Ge J., Li R., Yuan P., Che B., Bu X., Shao H. et al. Serum tissue inhibitor of metalloproteinase-1 and risk of cognitive impairment after acute ischaemic stroke // Cell. Mol. Med. 2020; jul;24(13):7470-7478.
  4. Howard P.J., Gaziano L., Rothwell P.M. Risk of stroke in relation to degree of asymptomatic carotid stenosis: a population-based cohort study, systematic review, and meta-analysis // Lancet Neurol. 2021;20(3):193-202.
  5. Huang L., Chen Y., Sun J., Xu L. Exploring the correlation between dietary zinc intake and stroke risk in adults based on NHANES database // Neurol Res. 2024;46(12):1113-1121.
  6. Mattern L., Chen C, Leslie A. McClure, Brockman J., Cushman M., Judd S., Kahe K. Serum zinc levels and incidence of ischemic stroke // Stroke. 2021;52:3953-3960.
  7. Ozyildirim S., Baltaci S.B. Cardiovascular Diseases and Zinc // Biol Trace Elem Res. 2023;1(4):1615-1626.
  8. Pu M., You Y., Wang X. Predictive value of serum matrix metalloproteinase 9 combined with tissue inhibitor of metalloproteinase 1 for post-stroke cognitive impairment // J Clin Neurosci. – 2022; nov;105:103-108.
  9. Shen T., Zhao Q., Luo Y., Wang T. Investigating the Role of Zinc in Atherosclerosis: A Review // Biomolecules. 2022;12(10):1358.
  10. Tamura Y. The Role of Zinc Homeostasis in the Prevention of Diabetes Mellitus and Cardiovascular Diseases // J. Atheroscler. Thromb. 2021;28:1109-1122. doi: 10.5551/jat.RV17057.
  11. Zielińska-Turek J., Dorobek M., Turek G., Dąbrowski J., Ziemba A., Andziak P., Barcikowska-Kotowicz. MMP-9, TIMP-1 and S100B protein as markers of ischemic stroke in patients after carotid artery endarterectomy // M.Pol Merkur Lekarski. 2022; jun 24;50(297):177-182.

    file

    download