31 -6 (38) 2021 — Tolipova Z.B., Karimov H.Ya., — EFFECTIVENESS OF THE ACTION OF A NEW AMINO ACID BLOOD SUBSTITUTE ON THE PARAMETERS OF THE GENERAL ANALYSIS OF BLOOD AND BONE MARROW IN EXPERIMENTAL PROTEIN STARVATION

EFFECTIVENESS OF THE ACTION OF A NEW AMINO ACID BLOOD SUBSTITUTE ON THE PARAMETERS OF THE GENERAL ANALYSIS OF BLOOD AND BONE MARROW IN EXPERIMENTAL PROTEIN STARVATION

Tolipova Z.B., Republican Specialized Scientific-Practical Medical Center of Hematology (RSSPMCH) of the MoH RUz

Karimov H.Ya., Republican Specialized Scientific-Practical Medical Center of Hematology (RSSPMCH) of the MoH RUz

Shevchenko L.I. Republican Specialized Scientific-Practical Medical Center of Hematology (RSSPMCH) of the MoH RUz

Resume

The aim of the study was to study the effectiveness of the action of the new amino acid blood substitute on the indicators of the general analysis of blood and bone marrow during protein starvation. On 120 male rats weighing from 180 to 200 g (n = 120), the protein starvation model was reproduced. After keeping the animals of the main group for 10 days on a protein-free diet, starting from the eleventh day, they were injected intraperitoneally with blood substitutes at a dose of 10 ml / kg of body weight for 10 days, after which the animals were slaughtered and blood taken for research. The research showed that the new amino acid blood substitute effectively restores the indicators of the general analysis of blood and bone marrow, not inferior in effectiveness to the preparation “Infezol 40”.

Key words: protein starvation, blood substitute, amino acids,  bone marrow

First page

175

Last page

180

For citation: Tolipova Z.B., Karimov H.Ya., Shevchenko L.I. EFFECTIVENESS OF THE ACTION OF A NEW AMINO ACID BLOOD SUBSTITUTE ON THE PARAMETERS OF THE GENERAL ANALYSIS OF BLOOD AND BONE MARROW IN EXPERIMENTAL PROTEIN STARVATION //New Day in Medicine 6(38)2021 175-180 https://cutt.ly/BYXXsGl

LIST OF REFERENCES:

1. Brovkina I.L., Konoplya A.I., Prokopenko L.G. Ergoprotective efficacy of vitamins that activate antioxidant, energy and anabolic processes during fasting // Kursk scientific and practical bulletin “Man and his health”, 2012, No. 1 – pp. 5-9.
2. Investigation of the general toxic properties of the new domestic infusion solution for amino acid parenteral nutrition with a single and course introduction
3. Ivanov D.S., Andreev S.V., Gapanovich V.N., Berdina E.L., Pavlenko V.S., Elina T.S.Republican Unitary Enterprise “Scientific and Practical Center LOTIOS”, Minsk, Republic of Belarus 2018 st. 148-154
4. Kamyshnikov V.S. Clinical laboratory research methods. Moscow “MEDpress_inform”. – 2011 – S. 1-750.
5. Karimov Kh.Ya., Shevchenko LI, Alimov TR, Isroilov AA, Ruziev US, Lubentsova OV. Evaluation of the effectiveness of the action of a new amino acid preparation in experimental protein-energy deficiency // Bulletin of the Tashkent Medical Academy. – 2019. – No. 4. – S. 47-50.
6. STUDY OF EFFICIENCY OF APPLICATION OF A NEW INFUSION
7. DRUG CONTAINING AMINO ACID IN EXPERIMENTAL PROTEIN
8. DEPRIVATION Larisa Ivanovna Shevchenko, Hamid Yakubovich Karimov, Ziyoda Bohodirovna Tolipova, Timur Raufovich Alimov, Olga Viktorovna Lubencova Republican Specialized Scientific and Practical Medical Center for
9. Hematology, Tashkent, Uzbekistan Journal of Xi’an Shiyou University, Natural Science Edition-2020 VOLUME 16 ISSUE 10 340-348 http://xisdxjxsu.asia
10. 6. Polyakovskaya OV, Dalinger AE, Infusion therapy: some aspects in modern conditions // Trauma, 2014. – No. 5 – T.15 – P. 11-14.
11. 7. Development of infusion solutions based on highly purified amino acids with a pathogenetically determined composition.
12. L.I. A. V. Nefedov Karavai, P.A. Loaf Grodno State University named after I. Kupala; Grodno State Medical University st 91-93
13. 8. Tolipova Z.B., Karimov Kh.Ya., Shevchenko L.I., Nigmatova M.S. Influence of a new amino acid blood substitute on morphological changes in the liver during protein starvation. Journal of Theoretical and Clinical Medicine. 5 / 2021. Articles 43-46.
14. 9. Cherniy V.I., Kolesnikov A.N., Oleinikov K.N., Egorov A.A., Biloshapka V.I. Rational fluid therapy. – Donetsk .: Druk TOV “Kashtan” – 2012 – S. 1-183.
15. 10. Cherniy V.I. Balanced infusion therapy in the perioperative period. Methods of liquid resuscitation of perioperative blood loss // Medicine of emergency conditions 2015 №2 (65) – P 37-43.
16. 11. Cherniy V.I. Actual aspects of infusion therapy // Medicine of emergency conditions 2015 №3 (66) – P. 43-53.
17. 12. Influence of a new antioxidant preparation on the state of lipid peroxidation and antioxidant system during protein starvation. Infection, Immunity and Pharmacology Scientific and Practical Journal 2/2020 Art 47-54 Karimov Kh.Ya., Shevchenko L.I., Tolipova Z.B., Sayfutdinova Z.A., Alimov T.R.
18. 13. Hu H., Liu D., Li P. Methane delays the senescence and browning in daylily buds by re-established redox homeostasis // J. Sci Food Agric. 2018 Mar; 98 (5) – S. 1977-1987.
19. 14. Kada Klouche, Jean J. Béraud Nutritional requirements in critically ill patients treated with intermittent renal replacement therapy // Critical Care Nephrology – pp 1473-1489.
20. 15. Masafumi Konosu, Takeshi Iwaya, Yusuke Kimura, Yuji Akiyama, Yoshihiro Shioi, Fumitaka Endo, Hiroyuki Nitta, Koki Otsuka, Keisuke Koeda and Akira Sasaki Peripheral vein infusions of amino acids facilitate recovery after esophagectomy for analysis Retroshage Annals of Medicine and Surgery, 2017-02-01, Volume 14, pp. 29-35.
21. 16. Peer review report 1 on “Peripheral vein infusions of amino acids facilitate recovery after esophagectomy for esophageal cancer: Retrospective cohort analysis” Annals of Medicine and Surgery, 2017-01-01, Vol. 13, pp. 69-69.
22. 17. Global Prevalence of Protein-Energy Wasting in Kidney Disease: Meta-
23. analysis of Contemporary Observational Studies From the International Society of Renal Nutrition and Metabolism Juan J. Carrero, Pharm, PhD, Fridtjof Thomas, Biostat, PhD, Krist of Nagy, MD, PhD, Journal of Renal Nutrition, Vol 28, No 6 (November), 2018: pp 380-392