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  • 67 -3 (77) 2025 - Khakimova L.R., Yusupov Sh.A. - IMPROVING THE DIAGNOSIS OF UROLITHIASIS IN CHILDREN IN PRIMARY HEALTH CARE

67 -3 (77) 2025 - Khakimova L.R., Yusupov Sh.A. - IMPROVING THE DIAGNOSIS OF UROLITHIASIS IN CHILDREN IN PRIMARY HEALTH CARE

IMPROVING THE DIAGNOSIS OF UROLITHIASIS IN CHILDREN IN PRIMARY HEALTH CARE

Khakimova L.R. - Samarkand State Medical University

Yusupov Sh.A. - Samarkand State Medical University

Sataev V.U. - Kazan State Medical Academy, Kazan, Republic of Tatarstan, Russia

Razin M.P. - Kirov State Medical University, Kirov, Russia

Kurbonov E.A. - Samarkand State Medical University

Khaidarov O.U.. - Samarkand State Medical University

Erkinjonov M.T. - Samarkand State Medical University

Resume

Urolithiasis is a very common disease in both adult and paediatric populations and represents not only a social and demographic but also an economic problem. Aim. To identify polymorphisms of genes associated with the development of urolithiasis in children of the Uzbek population. Material and methods. The study was conducted in the Specialised Children's Surgical Clinic of Samarkand State Medical University in two stages, in the period from 2012-2019. At the first stage, a retrospective analysis of the case histories of 652 admissions was carried out. At the second stage, a prospective study of 200 children aged from 1 to 17 years, of whom 100 children were diagnosed with urolithiasis (main group), and 100 children in the control group, who did not have urolithiasis, was conducted. Immunogenetic studies of vitamin D receptor (VDR), IL-1β, urokinase genes were performed. Results: the obtained results suggest that variants of vitamin D receptor (VDR), IL-1β and urokinase genes play an important role in the development of urolithiasis. A statistically significant association of F/f+f/f genotypes of the VDR gene (Fok-1) with urolithiasis was found in the studied groups, which was 1.3 times more frequent in the main group than in the control group. A statistically significant C/C allele of the IL-1β gene and urokinase 3'-UTR T/C was also detected in the main group. Conclusion: the role of immunogenetic method of urolithiasis prognosis in the detection of predisposition to the disease with the study of the distribution of genotypes of polymorphic markers of genes of vitamin D receptor (VDR), interleukin-1β and urokinase, which proves the importance of immunogenetic factors in the pathogenesis of urolithiasis development in children of Uzbek population, which are predictors of its development at the preclinical stage of the disease.

Key words: urolithiasis in children, early diagnosis, prognosis, risk factors, genetic factors, prelithiasis, primary health care.

First page

370

Last page

378

For citation:Khakimova L.R., Yusupov Sh.A., Sataev V.U., Razin M.P., Kurbonov E.A., Khaidarov O.U., Erkinjonov M.T. - IMPROVING THE DIAGNOSIS OF UROLITHIASIS IN CHILDREN IN PRIMARY HEALTH CARE//New Day in Medicine 3(77)2025 370-378 https://https://newdayworldmedicine.com/en/new_day_medicine/3-77-2025

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