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35 -6 (38) 2021 — Karimov M.Sh., Eshmurzaeva A.A., — ROLE OF IMMUNOGENETIC MARKERS IN THE DEVELOPMENT OF RHEUMATOID ARTHRITIS

ROLE OF IMMUNOGENETIC MARKERS IN THE DEVELOPMENT OF RHEUMATOID ARTHRITIS

Karimov M.Sh. Tashkent Medical Academy

Eshmurzaeva A.A. Tashkent Medical Academy

Sibirkina M.V. Tashkent Medical Academy

Resume

In the course of the studies, it was revealed that the G allele and the heterozygous A / G genotype of the IL17F gene (rs763780) are significantly higher among patients with RA compared to the control group.

In particular, the most significant differences were found in patients with the articular-visceral form of the disease, in whom the G allele exceeded the proportion of carriage in the control statistically significantly 2.58 times (χ2 = 4.512; P = 0.037; OR = 2.58; 95% CI: 1.076 -6.188), and on the part of the heterozygous genotype A / G there was a clear tendency to increase its frequency by more than two times (χ2 = 2.011; P = 0.165; OR = 2.068; 95% CI: 0758-5.645), which in in turn, indicates the possible participation of the studied polymorphism in the pathogenesis of RA.

Key words: rheumatoid arthritis, IL17F gene rs763780 polymorphism, carriage, allele, genotype, developmental factors, research methods.

First page

201

Last page

207

For citation: Karimov M.Sh., Eshmurzaeva A.A., Sibirkina M.V. ROLE OF IMMUNOGENETIC MARKERS IN THE DEVELOPMENT OF RHEUMATOID ARTHRITIS //New Day in Medicine 6(38)2021 201-207 https://cutt.ly/cYXCycZ

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