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  • 190 -12 (74) 2025 - Khamrakulov T.Z. - EVALUATION OF THE IMPACT OF ACE2 AND ANGIOTENSIN II ON PATHOLOGICAL PROCESSES IN COVID-19: A LITERATURE REVIEW

190 -12 (74) 2025 - Khamrakulov T.Z. - EVALUATION OF THE IMPACT OF ACE2 AND ANGIOTENSIN II ON PATHOLOGICAL PROCESSES IN COVID-19: A LITERATURE REVIEW

EVALUATION OF THE IMPACT OF ACE2 AND ANGIOTENSIN II ON PATHOLOGICAL PROCESSES IN COVID-19: A LITERATURE REVIEW

Khamrakulov T.Z. - Fergana Medical Institute of Public Health

Resume

The aim of this study is to systematically review the literature on the role of angiotensin-converting enzyme 2 (ACE2) and angiotensin II (Ang II) in the pathogenesis of COVID-19. Research indicates that the binding of SARS-CoV-2 to ACE2 results in reduced receptor expression and a subsequent imbalance in the renin-angiotensin system, leading to an accumulation of Ang II. Elevated Ang II levels are associated with an enhanced inflammatory response, thrombosis, endothelial dysfunction, and the development of severe disease manifestations such as acute respiratory distress syndrome. This review examines molecular mechanisms of viral interaction with the receptor, clinical data, and evidence supporting the efficacy of therapies aimed at normalizing the renin-angiotensin system using RAS inhibitors. The findings underscore the potential of targeted therapeutic approaches to mitigate the severity of COVID-19 and improve patient outcomes.

Keywords: ACE2, Angiotensin II, COVID-19, Renin-Angiotensin System, Pathogenesis, RAS Inhibitors, Inflammation, Thrombosis

First page

990

Last page

994

For citation:Khamrakulov T.Z. - EVALUATION OF THE IMPACT OF ACE2 AND ANGIOTENSIN II ON PATHOLOGICAL PROCESSES IN COVID-19: A LITERATURE REVIEW//New Day in Medicine 12(74)2024 990-994 https://https://newdayworldmedicine.com/en/new_day_medicine/12-74-2024

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