• Home
  • NEW DAY MEDICINE
  • 4 (78) 2025
  • 23 -4 (76) 2025 - Mukhamedova Sh.T., Abdieva N.R. - CYTOKINE STATUS OF PREMATURE NEWBORNS WITH DISORDERED INTESTINAL MICROBIOME

23 -4 (76) 2025 - Mukhamedova Sh.T., Abdieva N.R. - CYTOKINE STATUS OF PREMATURE NEWBORNS WITH DISORDERED INTESTINAL MICROBIOME

CYTOKINE STATUS OF PREMATURE NEWBORNS WITH DISORDERED INTESTINAL MICROBIOME

Mukhamedova Sh.T. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Abdieva N.R. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Thus, the study of the cytokine status in premature infants demonstrated an increase in the content of IL-1β in the main groups in relation to healthy newborns. IL-10 was also increased by 1.4 times in comparison with the control values. This condition is explained by premature birth, functional immaturity of the immune system and hyperactivation of protective and adaptive mechanisms in premature infants, but in parallel it acts as a diagnostic marker of the systemic inflammatory response. Newborns with elevated IL-1β concentrations were included in the high-risk group for sepsis and received additional antibacterial therapy.

Keywords: Premature infants, cytokine status, intestinal microbiome

First page

137

Last page

142

For citation:Mukhamedova Sh.T., Abdieva N.R. - CYTOKINE STATUS OF PREMATURE NEWBORNS WITH DISORDERED INTESTINAL MICROBIOME//New Day in Medicine 4(78)2025 137-142 https://newdayworldmedicine.com/en/new_day_medicine/4-78-2025

List of References

  1. Володин Н.Н., Дегтярева М.В. Роль про- и противовоспалительных цитокинов в иммунной адаптации новорожденных детей. // International Journal on Immunorehabilitation, 2018 April;2(1):175-185.
  2. Николаева И.В., Царегородцев А.Д., Шайхиева Г.С. Формирование кишечной микробиоты ребенка и факторы, влияющие на этот процесс. // Российский вестник перинатологии и педиатрии, 2018;63:(3)
  3. Припутневич Т.В., Исаева Е.Л.,Муравьева В.В., Месян М.К. , Зубков В.В. , Николаева А.В., Бембеева Б.О., Тимофеева Л.А., Козлова А.А., Макаров В.В., Юдин С.М. Становление микробиоты кишечника доношенных и поздних недоношенных детей, рожденных самопроизвольно и путем операции кесарева сечения. // Неонатология: новости, мнения, обучение. 2023;11(1):45.
  4. Navruzova Sh.I., Mukhamedova Sh.T. Tsitokin profile of newborns with systemic inflammatory response syndrome // Journal of theoretical and clinical medicine. 2018;4:28-31.
  5. Oradova A.Sh., Ustenova G.O., Stabaeva G.S. Methods of research of cytokines // Medicine. 2014;4:.84-87.
  6. Simbirtsev A.S. Tsitokiny: classification and biological functions. // Cytokines and inflammation. 2004;3(2):16-23.
  7. Tabolin V.A., Degtyareva M.V., Polyakova O.V. // 9th Congress of Pediatricians of Russia “Children's Healthcare in Russia: Development Strategies.” / M., 2001; 560 pp.

    file

    download