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  • 25 -4 (78) 2025 - Zakirova N.R. - METHODS OF INVESTIGATING SPECIFIC ASPECTS OF SPLEEN MORPHOMETRIC PARAMETERS IN EXPERIMENTAL BREAST CANCER CHEMOTHERAPY

25 -4 (78) 2025 - Zakirova N.R. - METHODS OF INVESTIGATING SPECIFIC ASPECTS OF SPLEEN MORPHOMETRIC PARAMETERS IN EXPERIMENTAL BREAST CANCER CHEMOTHERAPY

METHODS OF INVESTIGATING SPECIFIC ASPECTS OF SPLEEN MORPHOMETRIC PARAMETERS IN EXPERIMENTAL BREAST CANCER CHEMOTHERAPY

Zakirova N.R. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Purpose of the work. The aim of the study is to study the normal structure of the spleen of rats and its morphometric indicators and biochemical aspects in the pathology of the spleen and its correction in chemotherapy (for example: cisplatin, paclitaxel and doxorubicin). Spleen (lien) is a parenchymal organ that performs immune, hematopoietic functions, participates in metabolism, in particular, iron and protein exchange. Like lymph nodes, it is an organ of lymphoid hematopoiesis and a biological filter. It is an organ that has the ability to change its size. The spleen, by reducing blood loss, increases the total amount of blood in the circulatory system, and in particular in ruminants and horses, it becomes a blood reservoir. This is the destruction of blood cells, mainly erythrocytes, which are ending their life, which is called the "erythrocyte graveyard". The breakdown products of red blood cells, in particular iron and oxygen, are recycled in the body. During embryonic life, the spleen serves as an organ of myeloid hematopoiesis. It also has the ability to produce, that is, it serves as a place where lymphocytes that are appropriately identified by antigens present in the blood can develop into immunologically competent cells. In most postnatal animals, the normal spleen is a hematopoietic organ that produces lymphoid, erythrocyte and granulocyte lineages, megakaryocytes, and cells.

Keywords. spleen, morphometric indicators, biochemical aspects, chemotherapy.

First page

147

Last page

151

For citation:Zakirova N.R. - METHODS OF INVESTIGATING SPECIFIC ASPECTS OF SPLEEN MORPHOMETRIC PARAMETERS IN EXPERIMENTAL BREAST CANCER CHEMOTHERAPY//New Day in Medicine 4(78)2025 147-151 https://newdayworldmedicine.com/en/new_day_medicine/4-78-2025

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