43 -6 (38) 2021 — Egamova S.Q. — CYTOGENETICS IN ACUTE LEUKEMIA

CYTOGENETICS IN ACUTE LEUKEMIA

Egamova S.Q. Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Cytogenetic analysis in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) revealed a large number of non-random chromosomal abnormalities. In many cases, molecular studies of these abnormalities have identified specific genes involved in the process of leukemogenesis. The most common chromosomal aberrations are associated with specific laboratory and clinical characteristics and are currently used as diagnostic and prognostic markers to help the clinician choose the most effective treatment. Specific chromosomal aberrations and their molecular analogs have been included in the World Health Organization classification of hematologic malignancies and, together with morphology, immunophenotype, and clinical features, are used to identify various forms of the disease. This review summarizes current views on the clinical relevance of key cytogenetic findings in AML and ALL in adults.

Keywords: acute leukemia, diagnostics, cytogenetics, chromosomal aberrations.

First page

244

Last page

249

For citation: Egamova S.Q. CYTOGENETICS IN ACUTE LEUKEMIA //New Day in Medicine 6(38)2021 244-249 https://cutt.ly/dY58N6v

LIST OF REFERENCES:

  1. Karimov KH.YA., Boboyev K.T., Assesorova YU.YU., Allanazorova B.R.// Tsitogeneticheskiye issledovaniya v meditsine: fundamental’nyye i prikladnyye aspekty. – Monografiya. Tashkent. “Yangi asr avlodi”-2014-str. 283.
  2. Karimov KH.YA., Saidov A.B, Boboyev K.T.// Fundamental’nyye i prikladnyye aspekty molekulyarnoy genetiki v meditsine. – Rukovodstvo. Tashkent. “Uzbekistan”.- 2016 – str.350.
  3. Karimov KH.YA., Boboyev K.T., Assesorova YU.YU., Allanazorova B.R.// Molekulyarnaya genetika ostrykh leykozakh. – Rukovodstvo. Tashkent. “Turonzaminziyo”- 2017 – str.373.
  4. Misyurin A.V. Tsitogeneticheskiye i molekulyarno – geneticheskiye faktory prognoza ostrykh miyeloidnykh leykozov // Klinicheskaya onkogematologiya. – 2017;10(2). – S.226- 234.
  5. Khoduleva S.A., Kravchenko D.V. Sovremennyye aspekty laboratornoy diagnostiki ostrykh leykozov // Problemy zdorov’ya i ekologii. 2010. – S. 96-101.
  6. Arber D.A., Borowitz M.J., Cessna M., et al. Initial diagnostic workup of acute leukemia: guideline from the College of American Pathologists and the American Society of Hematology // Arch Pathol Lab Med. 2017. 141:1342–1393.
  7. Döhner H., Estey E., Grimwade D., et al. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel // Blood. 2017. 129:424–447.
  8. Papaemmanuil E., Gerstung M., Bullinger L., et al. Genomic classification and prognosis in acute myeloid leukemia // N Engl J Med. 2016. 374:2209–2221.
  9. Walter R.B., Othus M., Burnett A.K., et al. Resistance prediction in AML: analysis of 4601 patients from MRC/ NCRI, HOVON/SAKK, SWOG and MD Anderson Cancer Center // Leukemia.2015. 29:312–320.

file

download