66 - 4 (78) 2025 - Sharipova B.E. - MORPHOLOGICAL ASPECTS OF THE ACINAR STRUCTURE OF THE PANCREAS IN COVID-19

MORPHOLOGICAL ASPECTS OF THE ACINAR STRUCTURE OF THE PANCREAS IN COVID-19

Sharipova B.E. - Tashkent Medical Academy

Resume

COVID-19 can also cause histioarchitectonic disorders, acinuses, hypersecretary disorders, hyperproduction of glands and secretion of eosinophils, hyperchromia of epithelial nuclei, damage to small capillaries and diapedesis, formation of granular conglomerates in epithelial cells, formation of massive necrobiosis in epithelial cells and segmental necrosis in acinuses, according to eyewitnesses, an explosion occurred. At the same time, according to the researchers, segmental necrosis in acinuses can be caused by damage to microcirculatory cells, which can lead to necrosis in the genitals.

Key words: pancreas, COVID-19, necrobiosis, pathomorphology, pancreatitis.

First page

408

Last page

413

For citation:Sharipova B.E. - MORPHOLOGICAL ASPECTS OF THE ACINAR STRUCTURE OF THE PANCREAS IN COVID-19//New Day in Medicine 4(78)2025 408-413 https://newdayworldmedicine.com/en/new_day_medicine/4-78-2025

List of References

  1. Bacaksız F, Ebik B, Ekin N, Kılıc J. Pancreatic damage in СOVID-19: Why? How? // Int J Clin Pract. 2021 Oct;75(10):e14692.
  2. Bruno G, Fabrizio C, Santoro CR, Buccoliero GB. Pancreatic injury in the course of coronavirus disease 2019 (COVID‐19): a not‐so‐rare occurrence. // J Med Virol. 2021;93:74–75.
  3. Correia de Sá T, Soares C, Rocha M. Acute pancreatitis and СOVID-19: A literature review // World J Gastrointest Surg. 2021 Jun 27;13(6):574-584
  4. Coate KC, Cha J, Shrestha S, Wang W. et al. SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells. // Cell Metab. 2020 Dec 1;32(6):1028-1040.e4.
  5. СOVID-19 and diabetes mellitus: from pathophysiology to clinical management / S. Lim, J.H. Bae, H.S. Kwon, M.A. Nauck // Nature Reviews Endocrinology. 2021;17(1):11-30.
  6. Cheung S, Delgado Fuentes A, Fetterman AD. Recurrent acute pancreatitis in a patient with COVID‐19 infection. // Am J Case Rep. 2020;21:e9270.
  7. СOVID-19 and diabetes mellitus: from pathophysiology to clinical management / S. Lim, J.H. Bae, H.S. Kwon, M.A. Nauck // Nature Reviews Endocrinology. 2021;17(1):11-30.
  8. Figueroa-Pizano MD, Campa-Mada AC, Carvajal-Millan E, Martinez-Robinson KG, Chu AR. The underlying mechanisms for severe СOVID-19 progression in people with diabetes mellitus: a critical review. // AIMS Public Health. 2021 Oct 26;8(4):720-742.
  9. Furong L, Xin Long BZ, Wanguang ZXC, Zhanguo Z. ACE2 expression in pancreas may cause pancreatic damage after SARS‐CoV‐2 infection. // Clin Gastroenterol Hepatol. 2020;18:2128‐2130.e2
  10. Grusova G, Bruha R, Bircakova B, Novak M, Lambert L, Michalek P, Tomas G, Burgetova A. Pancreatic Injury in Patients with SARS-Cov-2 (СOVID-19) Infection: A Retrospective Analysis of CT Findings. // Gastroenterol Res Pract. 2021 Oct 31;2021:5390337
  11. Goyal H, Sachdeva S, Perisetti A, Mann R, Inamdar S, Tharian B. Hyperlipasemia and Potential Pancreatic Injury Patterns in СOVID-19: A Marker of Severity or Innocent Bystander? // Gastroenterology. 2021 Feb;160(3):946-948
  12. Goyal H, Kopel J, Ristić B, Perisetti A, Anastasiou J, Chandan S, Tharian B, Inamdar S. The pancreas and СOVID-19: a clinical conundrum. // Am J Transl Res. 2021 Oct 15;13(10):11004-11013
  13. Hanley B, Naresh KN, Roufosse C, et al. Histopathological findings and viral tropism in UK patients with severe fatal COVID‐19: a post‐mortem study. // Lancet Microbe. 2020;1:e245‐e253
  14. Heurich A, Hofmann-Winkler H, Gierer S, Liepold T, Jahn O, Pöhlmann S. TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein. // J Virol. 2014 Jan; 88(2):1293-307
  15. Hamming I, Timens W, Bulthuis ML, Lely AT, Navis G, van Goor H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. // J Pathol. 2004 Jun;203(2):631-7.

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