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  • 85 -4 (78) 2025 - Umurov B.F. - PATHOMORPHOLOGICAL CHANGES IN SKELETAL MUSCLE TISSUE OF EXPERIMENTAL RATS UNDER THE INFLUENCE OF CERTAIN DRUGS

85 -4 (78) 2025 - Umurov B.F. - PATHOMORPHOLOGICAL CHANGES IN SKELETAL MUSCLE TISSUE OF EXPERIMENTAL RATS UNDER THE INFLUENCE OF CERTAIN DRUGS

PATHOMORPHOLOGICAL CHANGES IN SKELETAL MUSCLE TISSUE OF EXPERIMENTAL RATS UNDER THE INFLUENCE OF CERTAIN DRUGS

Umurov B.F. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

This study investigates the pathomorphological changes in skeletal muscle tissue of experimental rats subjected to the effects of certain pharmaceutical agents. The research aims to analyze histological and structural alterations in muscle fibers, connective tissues, and cellular components induced by drug exposure. A controlled experimental design was employed, where rats were administered specific drug formulations over a defined period. Skeletal muscle samples were collected and examined using histopathological techniques, including hematoxylin and eosin (H&E) staining, immunohistochemistry, and electron microscopy. The results revealed significant morphological modifications such as muscle fiber atrophy, necrosis, fibrosis, and inflammatory infiltration, varying with drug type and dosage. These findings provide insight into the potential adverse effects of certain drugs on skeletal muscles, contributing to the understanding of drug-induced myopathies. Further research is necessary to elucidate the molecular mechanisms underlying these pathological changes and to develop protective strategies against drug-induced muscle damage.

Keywords. Pathomorphology, skeletal muscle, experimental rats, drug-induced myopathy, histopathology, muscle atrophy, fibrosis, inflammation, necrosis, pharmacotoxicology

First page

507

Last page

512

For citation:Umurov B.F. - PATHOMORPHOLOGICAL CHANGES IN SKELETAL MUSCLE TISSUE OF EXPERIMENTAL RATS UNDER THE INFLUENCE OF CERTAIN DRUGS//New Day in Medicine 4(78)2025 507-512 https://newdayworldmedicine.com/en/new_day_medicine/4-78-2025

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