106 -5 (78) 2025 - Aytmuratova U.K., Azamatov A.A. - ANALGESIC ACTIVITY OF TRIAZOLE DERIVATIVE IN ACUTE PAIN SYNDROME

ANALGESIC ACTIVITY OF TRIAZOLE DERIVATIVE IN ACUTE PAIN SYNDROME

Aytmuratova U.K. - Scientific research institute of chemistry of plant substances named after academician S.Yu.Yunusov Uzbekistan

Azamatov A.A. - Scientific research institute of chemistry of plant substances named after academician S.Yu.Yunusov Uzbekistan

Tursunxodjaeva F.M. - Scientific research institute of chemistry of plant substances named after academician S.Yu.Yunusov Uzbekistan

Resume

The most common way to manage acute pain is by using analgesics, the consumption of which is steadily increasing not only abroad but also in our country. This article provides information on the analgesic effect of a newly synthesized triazole derivative on acute pain syndrome, which affects both spinal and supraspinal levels. No noticeable analgesic effect was found in the «Hot Plate» test at low doses of the test substance. At doses of 100.0 and 150.0 mg/kg, it exhibited higher analgesic activity, prolonging the latent period of pain syndrome by 1.2 and 1.3 times, respectively, compared with the control group. In the «Hot Water» test, the test substance showed significant analgesic activity at all doses at 45°C. An increase in water temperature to 50°C and 55°C led to a decrease in the antinociceptive properties of the substance. The substance demonstrated high analgesic activity at doses of 100.0 and 150.0 mg/kg compared with other doses.

Keywords: triazole, nociceptor, hot plate test, hot water test

First page

615

Last page

620

For citation:Aytmuratova U.K., Azamatov A.A., Tursunxodjaeva F.M. - ANALGESIC ACTIVITY OF TRIAZOLE DERIVATIVE IN ACUTE PAIN SYNDROME//New Day in Medicine 4(78)2025 615-620 https://newdayworldmedicine.com/en/new_day_medicine/4-78-2025

List of References

  1. Айтмуратова У.К., Ортиков И С., Азаматов А.А., Турсунходжаева Ф.М., Элмурадов Б.Ж., Абдугофуров И. Острая токсичность и анальгетическая активность 4-(4-((4-метоксикарбонил) фенокси) метил)-1Н-1,2,3-триазол-1-ил) бензойная кислоты. // Инфекция, иммунитет и фармакология. 2023;3:25-34
  2. Лесная О.А. Боль в практике врача: сложный феномен и непростые пути решения. // Трудный пациент. 2019. 3(17):21-26 DOI: 10.24411/2074-1995-2019-10014
  3. Миронов А.Н. Руководство по проведению доклинических исследований лекарственных средств. М: Гриф и К. 2012.-197
  4. Цурко В.В., Шавловская О.А., Малышева Н.В. Боль как периферический феномен дорсопатии: приоритет местной терапии. // РМЖ. 2013;21:1051.
  5. Adrienne E. Dubin and Ardem Patapoutian. Nociceptors: the sensors of the pain pathway. // The Journal of Clinical Investigation. 2010;120(11)
  6. Allan I. Basbaum, Diana M. Bautista, Grégory Scherrer, and David Julius. Cellular and Molecular Mechanisms of Pain. // NIH Public Access Author Manuscript. 2009;139(2):267–284. doi:10.1016/j.cell.2009.09.028.
  7. Aytmuratova U.K., Azamatov A.A., Ortikov I.S., Tursunkhodzhaeva F.M. Investigation of the analgesic and anti-inflammatory activity of a newly synthesized 1,2,3-triazole derivative. // Frontiers in Health Informatics. 2024;13(6):686-693
  8. Aytmuratova U.K., Ortikov I.S., Аzamatov А.А., Ashurmetov R.I., Тursunxodjayeva F.М. Yangi sintez qilingan moddaning biologik faolliklarini o‘rganish. // Farmatsiya va farmakologiya. 2024;3(9):116-123
  9. European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes, ETS №123, Strasbourg 1986.
  10. Invention patent No. IAP 7858 Derivatives of 1H-1,2,3-triazole with analgesic and anti-inflammatory effects. 2024
  11. Mario Campero, Jordi Serra and Jose L. Ochoa. C-polymodal nociceptors activated by noxious low temperature in human skin. // Journal of Physiology. 1996, 497.2:565-572
  12. Mun Fei Yam, Yean Chun Loh, Chu Shan Tan et.al. General Pathways of Pain Sensation and the Major Neurotransmitters Involved in Pain Regulation. // Molecular Sciences. 2018, 19:2164; doi:10.3390/ijms19082164
  13. Sarah E. E. Mills, Karen P. Nicolson and Blair H. Smith. Chronic pain: a review of its epidemiology and associated factors in population-based studies. // British Journal of Anaesthesia. 2019;123(2):273-283. doi: 10.1016/j.bja.2019.03.023
  14. Thi Ngoc Mai Nguyen, Dana Clarissa Laetsch, Li-Ju Chen et.al. Pain severity and analgesics use in the community-dwelling older population: a drug utilization study from Germany. // European Journal of Clinical Pharmacology. 2020;76:1695-1707. https://doi.org/10.1007/s00228-020-02954-5
  15. Tulyaganov R.T., Fayziyeva Z.T., Sultanova R.X., Abdixakimov A.N. Klinikagacha bo‘lgan farmakologik izlanish asoslari (darslik) «INVEST BOOK» Toshkent 2024; 216 b.

    file

    download