1 -1 (39) 2022 — Mukhitdinova K.Ο., Aleinik V.A., — EFFECT OF THE COMPLEX OF CONTRICAL AND HEPARIN ON CHANGE OF IMMUNOLOGICAL INDICATORS IN WOMEN IN EARLY PERIODS OF PREGNANCY

EFFECT OF THE COMPLEX OF CONTRICAL AND HEPARIN ON CHANGE OF IMMUNOLOGICAL INDICATORS IN WOMEN IN EARLY PERIODS OF PREGNANCY

Muxitdinova K.Ο., Andijan State Medical Institute, Andijan, Uzbekistan

Aleinik V.A., Andijan State Medical Institute, Andijan, Uzbekistan

Babich S.M., Andijan State Medical Institute, Andijan, Uzbekistan

Negmatshaeva X.N., Andijan State Medical Institute, Andijan, Uzbekistan

Ibragimova S.R., Andijan State Medical Institute, Andijan, Uzbekistan

Shokirova S.M. Andijan State Medical Institute, Andijan, Uzbekistan

Resume

The work studied the effect of a complex of counterkals and heparin on changes in immunological parameters in women in early pregnancy with an excessive pro-inflammatory immune response and insufficient corrective response of protease inhibitors and TGF-β1. It was concluded that an excessive pro-inflammatory immune response in early pregnancy and an insufficient corrective response of protease inhibitors and TGF-β1 can create unfavorable conditions for the course of early pregnancy and the development of miscarriages. The use of pregravid treatment with a complex of counterkal and heparin helps to reduce the excessive pro-inflammatory immune response in the early stages of pregnancy, as well as to restore protease inhibitors and TGF-β1, which can contribute to a favorable course of pregnancy in the early stages and the development of a full-fledged pregnancy.

Key words: interleukins, protease inhibitors, early pregnancy, miscarriage, infections of the genitourinary system, contrikal, heparin.

First page

5

Last page

10

For citation: Mukhitdinova K.Ο., Aleinik V.A., Babich S.M., Negmatshaeva Kh.N., Ibragimova S.R., Shokirova S.M. EFFECT OF THE COMPLEX OF CONTRICAL AND HEPARIN ON CHANGE OF IMMUNOLOGICAL INDICATORS IN WOMEN IN EARLY PERIODS OF PREGNANCY //New Day in Medicine 1(39)2022 https://cutt.ly/ZU7Gyzt

LIST OF REFERENCES:

1. Baufreton C. et al. Heparin coating with aprotinin reduces blood activation during coronary artery operations //The Annals of thoracic surgery. – 1997. – Т. 63. – №. 1. – С. 50-56.
2. Greilich, P.E., Okada, K., Latham, P., Kumar, R.R., & Jessen, M. E. Aprotinin but not ε-aminocaproic acid decreases interleukin-10 after cardiac surgery with extracorporeal circulation: randomized, double-blind, placebo-controlled study in patients receiving aprotinin and ε-aminocaproic acid //Circulation. – 2001. – Т. 104. – №. 1. – С. 265- 269.
3. Harig F., Feyrer R., Mahmoud F.O., Blum U., Von der Emde J. Reducing the post-pump syndrome by using heparin-coated circuits, steroids, or aprotinin. The Thoracic and cardiovascular surgeon. 1999 Apr; 47(02):111-118.
4. Hill G. E., Diego R. P., Pohorecki R. Aprotinin enhances the endogenous release of interleukin-10 after cardiac operations //The Annals of thoracic surgery. – 1998. – Т. 65. – №. 1. – С. 66-69.
5. Hill G.E., Alonso A., Spurzem J.R., Stammers A.H., & Robbins R.A.  Aprotinin and methylprednisolone equally blunt cardiopulmonary bypass–induced inflammation in humans //The Journal of thoracic and cardiovascular surgery. – 1995. – Т. 110. – №. 6. – С. 1658-1662.
6. McCaffrey T.A., Falcone D.J., Vicente D., Du B., Consigli S., & Borth W. Protection of transforming growth factor β activity by heparin and fucoidan //Journal of cellular physiology. – 1994. – Т. 159. – №. 1. – С. 51-59.
7. Molor-Erdene P. et al. Urinary trypsin inhibitor reduces LPS-induced hypotension by suppressing tumor necrosis factor-α production through inhibition of Egr-1 expression //American Journal of Physiology-Heart and Circulatory Physiology. – 2005. – Т. 288. – №. 3. – С. H1265-H1271.
8. Robertson S.A., Guerin L.R., Bromfield J.J., Branson K.M., Ahlström A.C., Care A.S.  Seminal fluid drives expansion of the CD4+ CD25+ T regulatory cell pool and induces tolerance to paternal alloantigens in mice. Biology of reproduction, 2009, 80(5), 1036-1045.
9. Shigetomi H., Onogi A., Kajiwara H., Yoshida S., Furukawa N., et al. Anti-inflammatory actions of serine protease inhibitors containing the Kunitz domain //Inflammation research. – 2010. – Т. 59. – №. 9. – С. 679-687. 
10. Sintsova  O.V., Monastyrnaya M.M., Pislyagin E.A., Menchinskaya E.S., Leychenko E.V., Aminin D.L., et al. Anti-inflammatory activity of a polypeptide from the Heteractis crispa sea anemone //Russian Journal of Bioorganic Chemistry. – 2015. – Т. 41. – №. 6. – С. 590-596.