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209 -4 (78) 2025 - Nosirova D.E., Dusanov A.D. - THE INFLUENCE OF CLINICAL AND IMMUNOLOGICAL ASPECTS ON THE DEVELOPMENT OF ULCERATIVE COLITIS

THE INFLUENCE OF CLINICAL AND IMMUNOLOGICAL ASPECTS ON THE DEVELOPMENT OF ULCERATIVE COLITIS

Nosirova D.E. - Samarkand State Medical University

Dusanov A.D. - Samarkand State Medical University

Resume

Nonspecific ulcerative colitis (NUC) remains one of the most urgent problems of gastroenterology today. This disease is a chronic diffuse inflammation of the rectal mucosa and submucosal layer, manifested by the following clinical symptoms: abdominal pain, frequent bowel movements, tenism and false stools, weight loss. Also, nonspecific ulcerative colitis can be accompanied by various extraintestinal symptoms, which causes certain difficulties in the early diagnosis and treatment of this disease. Non-specific ulcerative colitis (NUC) is medically and socially important, as it causes severe complications, poor prognosis, and difficulties in diagnosis and treatment. Epidemiological studies show that the annual incidence of NUC is 10.4-12 cases per 100,000 people, with a prevalence of 35-100 cases per 100,000 people. NUC is three times more common than Crohn's disease. At present, the main emphasis in the pathogenesis of NCD is on the body's immune system. In the first studies of immune system disorders in non-specific ulcerative colitis (NUC), the finding of lymphoid tissue elements of the intestinal mucosa indicates disturbances in the immune status of the body. The presence of plasma cells, eosinophils, granulocytes, basophils in such infiltrates indicates changes in the immune system, an increase in the number of macrophages indicates phagocytic activity. Studying the characteristics of changes in the immune system depending on the severity and form of the disease, the activity of the pathological process in the large intestine, developing clinical and immunological diagnostic criteria, forecasting the consequences of the disease, and developing the principles of immunocorrective therapy are currently considered relevant

Keywords: immunity, colon, immunocorrection, lymphocytes, genetic predisposition

First page

1152

Last page

1156

For citation:Nosirova D.E., Dusanov A.D. - THE INFLUENCE OF CLINICAL AND IMMUNOLOGICAL ASPECTS ON THE DEVELOPMENT OF ULCERATIVE COLITIS//New Day in Medicine 4(78)2025 1152-1156 https://newdayworldmedicine.com/en/new_day_medicine/4-78-2025

List of References

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